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Portal > Offres > Offre UMR8165-YOLPRE-001 - "H/F" Radiothérapie par mini-faisceaux de protons : optimisation de la génération des faisceaux - M/F

"H/F" Proton minibeam radiation therapy: optimisation of minibeam generation

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Français - Anglais

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General information

Reference : UMR8165-YOLPRE-001
Workplace : ORSAY
Date of publication : Friday, April 05, 2019
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 October 2019
Proportion of work : Full time
Remuneration : From 3165.11 € pre-tax depending on experience
Desired level of education : PhD
Experience required : Indifferent


We are seeking an enthusiast fellow for a fully-funded, two years' position starting in Autumn 2019 working in the “New approaches in Radiation therapy” team at the IMNC lab (CNRS UMR8165, Campus d'Orsay, 25 km south of Paris), in close collaboration with the Institut Curie - Orsay Proton therapy center. The successful candidate will be involved in the development of an innovative and promising radiotherapy technique, called proton minibeam radiation therapy (pMBRT). pMBRT has been shown to drastically reduced neurotoxicity while providing an equivalent or superior tumor (glioma) control than standard RT in small animal experiments. In particular, the postdoctoral fellow will actively work in the optimisation of proton minibeam generation (from beam transport to quality assurance and treatment planning) to prepare the forthcoming clinical trials.


-Monte Carlo simulations
-Beam dynamics calculations
-Experimental dosimetry


-PhD in or related to particle acceleration techniques preferably. Alternatively, candidates with a PhD in Medical physics or in radiation physics and relevant experience will also be considered.
-Background in radiotherapy is an asset.
-Experience in Monte Carlo simulations and coding is recommended/appreciated

Work Context

The postdoctoral fellow will develop his work in the frame of an ERC consolidator grant whose main objectives are to disentangle the biological mechanisms involved in tumor control and normal tissue preservation, as well to optimise the method for minibeam generation and to develop a complete set of dosimetric tools adequate for patient treatments.
The “New Approaches in RAdiotherapy” team is a pioneer the conception and development of innovative methods based on the use of the spatial fractionation of the dose. This strategy has already shown a remarkable reduction in side effects of the radiation. Since we do not believe in frontiers, NARA was born in 2013 with an interdisplinary character and international composition. We work at the interphase between medical physics, computing (Monte Carlo simulations), and radiobiology.
The work will be done in tight collaboration with Orsay proton therapy center. Part of the Radiation Oncology Department of the Institut Curie, the ICPO, has been treating patients since 1991, being the first protontherapy facility in France. The two existing passive beamlines were built by the ICPO physics and technical team whose strong background allows the development of new clinical and research applications for proton therapy. For many years, dedicated resources (beam time, manpower) are available for research programs. The teams have a long experience in research collaborations with the CNRS, CEA and European centers in radioprotection, treatment planning, robotics, dosimetry, beam modelling, radiation biology and clinical trials.

Constraints and risks


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