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Reference : UMR9198-JACMON-001
Workplace : GIF SUR YVETTE
Date of publication : Tuesday, June 23, 2020
Scientific Responsible name : Jacques Montagne
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
How the environment modulates tumor progression:
The social environment is known to affect behavior and fitness of individuals. In humans, physicists often consider that psychological well-being contributes to health recovery, although the underlying physiological mechanisms remain mysterious. Unbiased studies using animal models have often shed light on these types of complex phenomenon. We have shown (Dawson et al 2018) a link between social environment and progression of a genetically induced intestinal tumor in Drosophila. We plan to decipher the physiological cascade induced by the social context. The working hypothesis is that a chemical signal (pheromone, microbiota ...) acts on the social behavior of sick flies, activating a neurological relay, which in turn modulates a physiological response (immunity, hormones, homeostatis ...) to control tumor progression. The doctoral project will focus on the study of the physiological functions linking social behavior to tumor growth based on differences in transcriptome (in progress).
This doctoral project is a collaboration between the team Growth and Metabolism in Drosophila (I2BC-UMR9198, INSB) and the pole Behavior pole (EGCE-UMR9191, INEE). The candidate must have a sense of teamwork and bases in genetics and cell physiology. Knowledge of the Drosophila model and / or of behavioral analyzes will be positively considered.
Dawson E, Bailly T, Dos Santos J, Moreno C, Devilliers M, Maroni B, Sueur C ,Casali, A, Ujvari B, Thomas F, Montagne J, Mery F 2018. Social environment mediates cancer progression in Drosophila. Nat Comm, 9, doi: 10.1038/s41467-018-05737-w.
Sueur C, Mery F 2017 . Social Interaction in Animals: Linking Experimental Approach and Social Network Analysis. Frontiers in psychology 8, 35
Garrido D, Rubin T, Poidevin M, Maroni B, LeRouzic A, Parvy JP, Montagne J 2015. Fatty Acid Synthase Cooperates with Glyoxalase 1 to Protect Against Sugar Toxicity. PLoS Genet: 11(2): e1004995.
French AS, Sellier M-J, Ali Agha M, Guigue AMA, Chabaud M-A, Reeb PD, Mitra A, Grau Y, Soustelle L, Marion-Poll F 2015. Dual mechanism for bitter avoidance in Drosophila. J Neurosci 35, 3990-4004.
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