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Three-years PhD position in Developmental Biology investigating the cellular and molecular determinants of tetrapod neck morphogenesis (M/F)

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 9 décembre 2021

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General information

Reference : UMR7221-EGLHEU-001
Workplace : PARIS 05
Date of publication : Thursday, November 18, 2021
Scientific Responsible name : Eglantine Heude
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 March 2022
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

The neck, specific to tetrapods, emerged congruent with limbs during the vertebrate water-to-land transition. This morphological innovation resulted from the adaptation of the musculoskeletal system and required profound developmental rearrangements. In vertebrates, the musculoskeletal systems of the head and trunk have different embryonic origins and their formation depends on distinct molecular mechanisms. The neck region constitutes a transition zone of mixed embryonic origin at the head-trunk interface and the morphogenetic actors regulating its formation remain elusive.
Taking advantages of the genetic tracing and conditional inactivation strategies in the mouse, the PhD student will explore the function of candidate genes in neck morphogenesis. Through the analysis of different key vertebrate species, she·he will compare the spatiotemporal expression of molecular actors of neck development and will study conservation and divergence in genetic programs taking place at the head-trunk transition. The data will permit to elucidate the developmental and evolutionary origins of the tetrapod neck and will bring new insights for the understanding of some human congenital disorders in which the neck musculoskeletal system is specifically affected.

Work Context

The National Museum of Natural History (MNHN), part of the Sorbonne University Alliance, constitutes an exceptional site of research in the heart of Paris.
The activity will be carried out within the CNRS unit « Physiologie moléculaire et Adaptation » (CNRS UMR7221) of the « Adaptations du Vivant » MNHN Department.
The candidate will benefit from the multidisciplinary training offered within the doctoral school « Science de la nature et de l'homme : évolution et écologie » (ED227). She·He will have the opportunity to use the imaging platforms of the MNHN, the Paris-Seine Institute of Biology and the Jacques Monod Institute.

Constraints and risks

Written and oral communication skills in English are a prerequisite.
The constraints of this position are related to the handling of different animal species (fish, salamander, lizard, mouse and chicken) present on site. The candidate will have to comply with bioethical regulations related to animal research.

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