En poursuivant votre navigation sur ce site, vous acceptez le dépôt de cookies dans votre navigateur. (En savoir plus)
Portail > Offres > Offre UPR5301-ISACAL-120 - Chercheur en glycobiochimie (H/F)

Glycobiochemistry researcher (M/F)

This offer is available in the following languages:
- Français-- Anglais

Date Limite Candidature : vendredi 1 mars 2024

Assurez-vous que votre profil candidat soit correctement renseigné avant de postuler

Informations générales

Intitulé de l'offre : Glycobiochemistry researcher (M/F) (H/F)
Référence : UPR5301-ISACAL-120
Nombre de Postes : 1
Lieu de travail : GRENOBLE
Date de publication : vendredi 9 février 2024
Type de contrat : CDD Scientifique
Durée du contrat : 12 mois
Date d'embauche prévue : 1 juin 2024
Quotité de travail : Temps complet
Rémunération : between 2905.76 € and 4081.77 € gross per month depending on experience
Niveau d'études souhaité : Niveau 8 - (Doctorat)
Expérience souhaitée : 1 à 4 années
Section(s) CN : Interactions, particles, nuclei, from laboratory to cosmos

Missions

Expression and characterisation of new enzymes for the production of bacterial cell wall oligosaccharides

Activités

Identification of new enzymes with potential for oligosaccharide production
Enzyme expression (in flask or bioreactor) in E. coli (in native form or in fusion with chaperones)
Enzyme purification and characterisation
Enzyme engineering

Compétences

The successful candidate will hold a PhD in biochemistry or microbiology. She will have solid skills in molecular biology (cloning, integration and genomic deletion methodologies) and enzymology (expression and functional characterisation of enzymes). Knowledge in glycobiology and in particular about enzymes acting on glycans is desirable. The candidate will need to be highly motivated by research, well-organised and independent, and motivated by multidisciplinarity.

Contexte de travail

The position is opened in the Chemistry and Biotechnology of Oligosaccharides CBO team at CERMAV (UPR CNRS 5301). CBO is a multidisciplinary team at the interface of glycochemistry, biochemistry and microbiology, whose research activities focus on the production of oligosaccharides and glycoconjugates for structure-function studies in the fields of human and plant health. Antibiotic resistance, a major public health issue, requires a detailed analysis of the metabolism of the bacterial wall, and more specifically of its main component: peptidoglycan. CBO has been working for several years on the chemo-enzymatic synthesis of this biopolymer (Chem. Eur. J. 2021, 27, 17637-17646; Asian J. Org. Chem. 2021, 10, 3290-3292; Chem. Eur. J, 2023, 29, e202202991). The person recruited will work in collaboration with the CBO's chemists and CERMAV microbiology platform to characterise new enzymes of peptidoglycan metabolism and discover new tools for its in vitro synthesis.
CERMAV is located on the Grenoble campus, with easy access from the city centre by bicycle or public transport. Located in the heart of the Alps, Grenoble is a dynamic place to live offering a wide range of outdoor activities in both summer and winter.