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Reference : UPR8241-OLIBAS-002
Workplace : TOULOUSE
Date of publication : Wednesday, April 14, 2021
Scientific Responsible name : Dr. Olivier Baslé
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Photocatalytic reactions, initially inspired by natural photosynthesis, have developed rapidly in recent decades.  The possibilities for future developments in this field, in particular in biohybrid photocatalysis (combination of metal complexes and biological substances) are important and promising.  Based on our recent work in the design of new photocatalysts,  and as part of a collaborative project funded by the French National Research Agency (ANR), the project consists of extending the concept of asymmetric catalysis based on DNA  to asymmetric DNA-based photocatalysis by developing novel, highly selective synthetic tools with applications in various asymmetric photocatalytic transformations. More specifically, the project aims to develop metallo-catalyzed systems, for which DNA is used as a chiral inducer in asymmetric cycloaddition reactions promoted by visible light in water.
 D. W. C. MacMillan et al., Chem. Rev. 2013, 113, 5322-5363.
 G. Roelfes et al., Chem. Eur. J. 2021, 27, 1430-1437.
 a) O. Baslé et al., Angew. Chem. Int. Ed. 2019, 58, 15244-15248. b) O. Baslé et al., Chem. Commun. 2019, 55, 6058-6061.
 a) M. Smietena, S. Arseniyadis, Org. Biomol. Chem. 2017, 15, 7072-7087. b) M. Smietena, S. Arseniyadis, Chimia, 2018, 72, 630-634. c) S. Arseniyadis, M. Smietena et al. ChemCatChem. 2019, 11, 5686-5704.
The Laboratoire de Chimie de Coordination (LCC) of the CNRS (www.lcc-toulouse.fr) is one of the best chemistry institutes in France. We have at our disposal very well equipped technical and analytical platforms for the daily support of scientific work. With more than 70 researchers divided into 15 teams, research at LCC places coordination chemistry as a central tool to tackle current issues related to climate change, energy transition and life sciences. This position is a 3-year doctorate fully funded by the French National Research Agency as part of a collaborative project with the University of Montpellier, Paris-Saclay University and Queen Mary University in London. The candidate will be supervised by Dr Olivier Baslé (LCC) and co-supervised by Dr Yves Canac (LLC).
The motivated candidate, preferably with a research master's degree in organic chemistry, with interests in photocatalysis, organic synthesis and coordination chemistry, must show excellent teamwork skills, as well as a good command of French and English (read, written, spoken). Knowledge in the field of life science is not mandatory.
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