Description du sujet de thèse

Evolution happens by small molecular level steps: mutations, insertions or deletions of segments of nucleotides, that over long times lead to new functional solutions. Most modifications are deleterious to structure or function and selected against. As a result, not all paths allowed by local evolutionary moves can be implemented in an evolving organism. The goal of this project is to estimate the space of possible evolutionary trajectories in enzyme evolution. We will use methods from statistical mechanics to consider different search scenarios.

Contexte de travail

The student will work in the group of T. Mora and A. Walczak that works on various questions of theoretical biophysics, as well as in the broader biophysics groups at LPENS and at the ENS bio institute.

Contraintes et risques

no risks