Description du sujet de thèse

This thesis project focuses on the formation and dynamics of peptide-based coacervates as protocell model systems. We will begin by exploring the minimal length and sequence requirements for peptide coacervates. Next, the project will assess how these coacervates influence polypeptide synthesis. In parallel, we will study whether polypeptide synthesis can directly trigger in situ coacervation, thereby linking polymerisation and phase separation. Finally, we will study the degradation of coacervates by proteolysis, enabling us to establish dynamic cycles of coacervate growth and decay, favouring the selective formation of specific polypeptides.

Contexte de travail

The candidate will work in two different laboratories: the 'BioPhysicalChemistry' team at the CRPP (Centre de Recherche Paul Pascal, https://www.crpp.cnrs.fr/) in Pessac, France, under the supervision of Nicolas Martin (https://www.crpp.cnrs.fr/nicolas-martin/) and the 'Polymer self-assembly and life sciences' team at the LCPO (Laboratoire de Chimie des Polymères Organiques, https://www.lcpo.fr/) in Pessac, France, under the supervision of Colin Bonduelle (https://www.lcpo.fr/people/faculties/colin-bonduelle).

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.

Contraintes et risques

The position is located in a sector covered by the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival be authorised by the competent MESR authority.

Informations complémentaires

The candidate recruited for this project will have a solid background in physical chemistry and soft matter, with a strong interest in interdisciplinary and team work. Skills in macromolecular chemistry would be appreciated.
Fluency in English (oral and written comprehension and expression) is required.