Description du sujet de thèse

Microtubules are cytoskeletal fibers that form complex macromolecular assemblies in cells, particularly in neurons where they are organized into dense bundles, both in axons and dendrites. These assemblies are organized by a wide range of microtubule-associated proteins (MAPs).
The proposed interdisciplinary project combines the expertise of both teams: Janke/Magiera and Pullarkat, to study how neuronal microtubule dynamics, regulated by posttranslational modifications of tubulin, affect axonal morphology and neuronal physiology. The work will combine established and unique model systems from both teams to determine how the tubulin code influences the behavior of MAPs in neurons, and how this controls the architecture and dynamics of the microtubule cytoskeleton. He will also study how this affects axonal morphology, particularly axon beading, which is generally linked to changes in neuronal physiology and is often observed in neurodegeneration.
This interdisciplinary project presents a unique opportunity to open new avenues for determining how regulation of the microtubule cytoskeleton in neurons affects neuronal physiology. Our project also has the potential to advance understanding of the mechanisms of cytoskeleton-related neurodegenerative disorders.

Contexte de travail

The "Regulation of Microtubule Dynamics by Tubulin Code" team is based at the Orsay (91) site of the Curie Institute Research Center, within UMR3348 CNRS. Part of the project will be carried out in the laboratory of Dr. Pramod Pullarkat, at the Raman Research Institute, in Bangalore, India.

Contraintes et risques

None