Profil Recherché

Titulaire d’un doctorat ou diplôme équivalent ou justifiant de titres et travaux scientifiques jugés équivalents par l’instance compétente de l’établissement. Il n’y a aucune condition d’âge ou de nationalité pour candidater. Tous les emplois CNRS sont accessibles aux personnes en situation de handicap en bénéficiant d’aménagement d’épreuves rendus nécessaires par la nature du handicap

Stratégie d'établissement

The CNRS is at the forefront of international research, notably due to its ability to foster breakthrough research through interdisciplinarity. The proposed Junior Professorship, based on two CNRS institutes, CNRS Biology and CNRS Chemistry, is fully in line with the CNRS mission to ensure the advancement of knowledge in all disciplinary fields, and here more particularly in the fields of innovation in chemistry for tomorrow's health applications. In its 2019-2023 contract of objectives, the CNRS has highlighted the growing demand for multifunctional materials, with optimized, combined or even extraordinary properties. The program proposed through this Junior Professorship is perfectly in line with this objective. Indeed, with the advent of 5P medicine, offering (nano)-molecules that can be custom-modulated according to a patient's intrinsic characteristics is a major challenge, and only multidisciplinary research will enable us to achieve this goal.
As part of the France 2030 plan, the objectives are to position France among the leaders in a dozen strategic sectors such as energy, health of the future, decarbonization of industry, food and agriculture... The research program presented here is a perfect response to this health of the future objective, with the development of theranostic objects based on the research of the two CNRS laboratories (ISTCT and LCS) hosting this Junior Professorship.

Stratégie du laboratoire d'accueil

ISTCT seeks to better understand the pathophysiology of hypoxic tumors (brain-lung-brain metastases), to identify new therapeutic strategies targeting the tumor and its microenvironment, and to assess the effects of anti-cancer treatments including radiotherapy (RT) on healthy tissues and their protection, using in vivo imaging (MRI, PET/CT) in particular. For several years now, ISTCT has been working on a nano-particle approach targeting tumor cells, in partnership with the LCS laboratory. The LCS is an internationally renowned laboratory in the field of nano-zeolite synthesis. The functionalization of these nanoparticles enables them to be used as carriers for sensitizing agents targeting cancer cells.
Collaboration between the 2 partners through this position will enable us to refine this nano-particle therapy strategy to combine various components (in particular by taking into account the tumor microenvironment) with the overall aim of offering a multimodal tumor targeting platform that can be adapted to suit individual needs. The Junior Professorship will enable the laboratory to strengthen its original research into intelligent, customizable chemistry tools, in order to offer innovative therapeutic and imaging (theranostics) tools.

Stratégie Internationale

The research project to be supported by this CPJ is part of an existing international initiative. Indeed, work on zeolites and their biomedical applications is already a major focus of the IRN France-China "Zeolites" project, in which both the LCS and ISTCT units are involved. This has already resulted in three joint international symposia (1 in China and 2 in France). More recently, work on zeolites and their biomedical applications has enabled the partner laboratories to win European MSCA-IF funding, whose research project is linked to that of the CPJ and is based on a partnership with an Italian laboratory, itself a partner in the "EuroNanoMed" consortium. CPJ will be able to strengthen this partnership, in particular by hosting foreign researchers and students, as has already been the case in the past. Given the importance of nanoparticles and the challenges they present, particularly for biomedical applications, the creation of an international training program open to both chemists and biologists would seem highly appropriate. The CPJ could be involved in masters courses at the University of Caen, summer-school courses as part of the IRN Zeolites program, and contribute to the development of a diploma and/or MOOC-type courses in this field.

Répertoire national des structures de recherche (RNSR) du laboratoire d'accueil

199612301T LCS Laboratoire de catalyse et spectrochimie
201722484V ISTCT Imagerie et stratégies thér

Résumé du projet scientifique

The main objective of the project is to custom-synthesise and validate in vivo new nanometric porous materials (zeolites) for biomedical applications. Nanozeolites are nanoparticles whose synthesis and ability to adsorb and deliver guest molecules can be perfectly controlled in a physiological context at a defined pH. The project focuses on 1) the development and validation of new biocompatible nanometric zeolites without organic materials and 2) their use in preclinical models to improve the efficacy of conventional treatments for brain tumours or other resistant tumours. In particular, hypoxia-induced radiation and chemoresistance, as well as other phenomena associated with tumour growth such as inflammation, will be targeted. There are more than 250 known zeolites. The new challenge for a project focusing on chemistry will be to control their properties through synthesis design in order to improve performance in terms of stability, selectivity and biocompatibility. For a biology-based project, therapeutic uses and multimodal imaging monitoring in relevant models will be proposed. These new compounds combined with the advanced characterisation and vectorisation of the molecules determined for biomedical applications constitute the ultimate interdisciplinary objective, with the aim of providing a theranostic platform adaptable to the biomedical context.

Résumé du projet d'enseignement

The activities of the recruited candidate will be part of the teaching programs at the University of Caen Normandy, through educational contributions in the field of chemistry–biology related to health. Depending on the candidate's profile, these activities may be developed within the departments of Chemistry or Biology.

Environnement Financier

• Total financé (dont package ANR) : 200 k€
• Total du projet : k€

Diffusion scientifique

The dissemination of the results will be done through world-class scientific productions: publications, patents, software... In addition, the results will be communicated to various targets such as scientific communities, media, decision makers, general public, schools, etc., with an adapted calendar. Specific tools may be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.

Science ouverte

The CNRS is developing a strong policy in favor of open science. Open science consists of making research results "as accessible as possible and closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its laboratories accessible , in particular through deposit in HAL. The data produced must also be made available and reusable, except for specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, to be more qualitative and to take into account all facets of the researcher's profession.

Science et société

The relationship between science and society is now recognized as a full dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will contribute to informing public decision-making. Participatory science initiatives may be initiated with actors from the project’s socio-economic and cultural eco-system.

Indicateurs

The activity will be evaluated in particular on the basis of scientific production (publications, software, patents, etc.), on institutional and private partnerships formalized by contracts, on international presence, on the promotion of work to multidisciplinary scientific communities, on innovation and its transfer to society and on scientific dissemination to non-specialist audiences.

Modalités d'organisation des auditions

Seul(e)s seront convoqué(e)s aux auditions les candidat(e)s sélectionné(e)s sur dossier par la commission de sélection