Profil Recherché

Titulaire d’un doctorat ou diplôme équivalent ou justifiant de titres et travaux scientifiques jugés équivalents par l’instance compétente de l’établissement. Il n’y a aucune condition d’âge ou de nationalité pour candidater. Tous les emplois CNRS sont accessibles aux personnes en situation de handicap en bénéficiant d’aménagement d’épreuves rendus nécessaires par la nature du handicap

Stratégie d'établissement

The CNRS is a national multi-disciplinary research organization dedicated to scientific excellence and the advancement of knowledge on the road to breakthrough innovations. One of the CNRS's objectives is to provide the necessary resources for research aimed at understanding the involvement of non-genetic components in the regulation of gene expression, and their impact on the development and response of organisms to the environment. This Junior Chair, which will enable the recruitment of a young scientist of international excellence in the field of understanding the fundamental role of non-genetically encoded chemical modifications of RNA, is therefore fully in line with the establishment's strategy.

Stratégie du laboratoire d'accueil

Based on scientific relevance, the candidate will be will be selected to work in the MCD (Molecular, Cellular and Developmental Biology) laboratory in Toulouse or in the IPS2 (Institute of Plant Sciences) in Saclay. The MCD teams develop fundamental research projects focused on understanding the mechanisms governing genome organization and function, cell division and mechanics, cell identity and development in eukaryotes and archaebacteria. The IPS2 research teams focus on understanding the genetic and molecular mechanisms that control the growth of terrestrial plants and their regulation by endogenous and exogenous signals of biotic or abiotic origin, particularly in relation to climate change. The two laboratories carry out integrative functional biology studies ranging from the molecule to the macromolecule, at the scale of the cell, the organ and the whole organism.

Stratégie Internationale

The creation of a research team focusing on the role of RNA chemical modifications will reinforce the CNRS's international strategy of scientific excellence. It will also reinforce a research theme that needs to be strengthened in France today. The profile sought for this professorship is also in line with the thematic framework of the International Research Centre (IRC) supported by the CNRS and the University of Arizona, which aims, among other things, to take up the challenge of understanding the mechanisms of plant response to the impact of environmental changes and induced stresses in particular, on plants.

Répertoire national des structures de recherche (RNSR) du laboratoire d'accueil

201521301T IPS2 Institut des Sciences des Plantes de Paris Saclay
202123704D MCD Unité de biologie m

Résumé du projet scientifique

All types of RNA, whether coding (messenger RNA) or non-coding (snRNA, snoRNA, miRNA, tRNA, ribosomal RNA, etc.), are decorated with chemical modifications, collectively known as epitranscriptomic marks. Over 160 types of epitranscriptomic marks have been identified to date, which impact on RNA maturation, stability, function or expression. Present in the vast majority of eukaryotes, it is now recognized that epitranscriptomic marks play a crucial role in the fine regulation of cellular activity in response to developmental or environmental signals, thus participating in the development, growth or physiological response of organisms to stress. The CNRS is opening a Junior Professorship to recruit a talented young scientist to carry out a research project focusing on the molecular, cellular and physiological roles of RNA modifications in eukaryotes. This functional biology project will be based on cutting-edge technologies and can be developed in any type of eukaryote, fungi, animals or terrestrial plants.

Résumé du projet d'enseignement

Teaching can take place within the teaching team of Toulouse University, within the teaching teams of the bachelor's and/or master's degrees in molecular and cellular biology. Alternatively, teaching can take place at doctoral level within the Ecole Doctorale Science du Végétal (Epigenomics), and at master level within the Ecole Universitaire de Recherche “Biologie Moléculaire des Plantes et des Microorganismes”, at Paris Saclay University.

Environnement Financier

• Total financé (dont package ANR) : 200 k€
• Total du projet : k€

Diffusion scientifique

The dissemination of the results will be done through world-class scientific productions: publications, patents, software... In addition, the results will be communicated to various targets such as scientific communities, media, decision makers, general public, schools, etc., with an adapted calendar. Specific tools may be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.

Science ouverte

The CNRS is developing a strong policy in favor of open science. Open science consists of making research results "as accessible as possible and closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its laboratories accessible , in particular through deposit in HAL. The data produced must also be made available and reusable, except for specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, to be more qualitative and to take into account all facets of the researcher's profession.

Science et société

The relationship between science and society is now recognized as a full dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will contribute to informing public decision-making. Participatory science initiatives may be initiated with actors from the project’s socio-economic and cultural eco-system.

Indicateurs

The activity will be evaluated in particular on the basis of scientific production (publications, software, patents, etc.), on institutional and private partnerships formalized by contracts, on international presence, on the promotion of work to multidisciplinary scientific communities, on innovation and its transfer to society and on scientific dissemination to non-specialist audiences.

Modalités d'organisation des auditions

Seul(e)s seront convoqué(e)s aux auditions les candidat(e)s sélectionné(e)s sur dossier par la commission de sélection