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Reference : UMR8612-JULNIC-003
Workplace : CHATENAY MALABRY
Date of publication : Thursday, November 18, 2021
Type of Contract : FTC Scientist
Contract Period : 18 months
Expected date of employment : 3 January 2022
Proportion of work : Full time
Remuneration : Between 2750 and 3900 € gross monthly depending on experience
Desired level of education : PhD
Experience required : 1 to 4 years
In the field of biomaterials, synthetic biodegradable polymers are mainly limited to two categories: polyesters (e.g., polycaprolactone, polylactide, polyglycolide and their copolymers) and polypeptides. However, there are many drawbacks and limitations to the synthesis of well-defined and functionalized polymers (e.g., complex synthesis, low structural and compositional diversity, difficult functionalization, etc.). Allowing the degradation of vinyl polymers appears to be a major challenge. In this spirit, the idea is to copolymerize a traditional vinyl monomer with a cyclic ketene acetal (CKA) comonomer, which is a precursor of biodegradable ester functions, via a radical ring-opening polymerization (rROP) mechanism. In this case, rROP has both the advantages of ring-opening and radical polymerization, and thus allows the radical synthesis of well-defined biodegradable copolymers with ester functions in the polymer backbone.
This project will attempt to diversify the families of degradable vinyl copolymers by copolymerizing various vinyl monomers with CKAs of varying structures, with a view to industrial use
Synthesis of degradable vinyl polymers by radical ring-opening polymerization
Characterization of the polymers
Essential skills in controlled radical polymerization and ring-opening radical polymerization
Essential skills in polymer characterization (SEC, NMR)
The project is based on a collaboration between the Institut Galien Paris Saclay and SNF
The person recruited will be under the supervision of Dr. Julien NICOLAS
Constraints and risks
No particular constraints or risks
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