Missions

A postdoctoral researcher position is available within the “Mechanotransduction: from the cell surface to the nucleus” team at the Institut Jacques Monod (UMR7592 CNRS/Université Paris Cité, Paris, France - www.ijm.fr/en/860/equipes/mecanotransduction. htm) to work on a project aimed at revealing the mechanotransduction mechanisms underlying epithelial plasticity. This project is in line with the team's general interest in understanding how macromolecular complexes transmit and transform mechanical signals within and between cells, and how these signals affect cellular functions such as adhesion, migration, proliferation, and transcriptional activity. To do this, the team applies and develops genetically modified tools, quantitative fluorescence microscopy, and micromanipulation approaches to quantitatively control and monitor molecular functions within living cells.

Activités

The successful candidate will
- participate in the design of the project,
- use and develop methodologies,
- carry out experiments,
- analyze and communicate the data,
- write reviews and research articles.
The candidate will use a wide range of approaches including advanced live-cell imaging (FRET, FLIM, FCS) cell biology (mammalian cell culture, transfection, molecular biology…) and cell and tissue micromanipulation.

Compétences

The candidate should have a PhD (or have it completed before the start of the position), in biology or in soft matter physics with a strong interest in biology. The candidate must be rigorous, have excellent organizational and teamwork skills, have the ability to lead, and be able to express himself / herself in English, written and spoken (the practice of French is not compulsory).

Contexte de travail

The Institut Jacques Monod (IJM), which is housed in a building of 1800 square meters, located on the new campus of the Paris left bank urban project, is one of the main centers of fundamental research in biology in Paris, and offers a multidisciplinary research environment. The IJM brings together thirty research groups working on cell and developmental biology, biophysics and genomics. The postdoctoral researcher will benefit from an extremely stimulating scientific environment, and will have access to state-of-the-art core facilities (live-cell imaging, electronic imaging and flow cytometry), located at the IJM.