Postdoctoral scientist M/F
New
- Researcher in FTC
- 12 mounth
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Centre interdisciplinaire de recherche en biologie
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
75231 PARIS 05
Contract Duration
12 mounth
Date of Hire
01/09/2026
Remuneration
3000 euros brut per month according to experience
Apply Application Deadline : 01 May 2026 23:59
Job Description
Missions
The Selimi Lab (www.fekrijeselimilab.com) at CIRB-Collège de France is seeking a highly motivated postdoctoral scientist to lead a project that aims to understand how the early life environment and neuronal activity impacts synapse diversification during postnatal development and the long-term functioning of the mammalian brain at the synapse-specific level.
Activity
Brain function relies on the development of complex neuronal circuits and specific synapses. Mutations in synaptic protein genes and environmental factors such as early life adversity are major factors in the etiology of neurodevelopmental and psychiatric disorders. Our research project will dissect the interplay between early life adversity, neuronal activity and genetic factors during the early postnatal development of neuronal circuits and its long-term consequences, using cerebellar Purkinje cells as a model system. This project stems from our recent research showing that synapse diversity is generated in a stepwise manner during postnatal development and that each synapse type follows specific rules for its specification (Paul et al. Nat. Neurosci. 2025; Veleanu et al. PNAS 2022). In addition, some synapse types might be more sensitive to changes in neuronal activity during the postnatal period (Paul et al. Nat Neurosci. 2025).
The cerebellum's involvement in a broad range of cognitive functions, beyond its well-known role in motor coordination and adaptation, is now recognized. Using neuron- and synapse-specific approaches in mice, in combination with a broad range of molecular, biochemical and imaging techniques, you will dissect how early life adversity modulates epigenetic marks in the mouse cerebellum, and the relationship with the development of molecular synapse identity and neural circuitry. This study has implications for our understanding of normal brain development, the impact of the early life environment and the etiology of the diversity of symptoms observed in various neurodevelopmental disorders.
Your Profil
Skills
Cellar Biology, neurosciences, molecular biology (cloning, ...), biochemistry (protein work)
- critical analysis of the litterature
- ability to adapt and implement new protocols
Your Work Environment
Our work is funded by several agencies, including Fondation pour la Recherche Médicale et la Ligue contre le Cancer. The CIRB offers a world-class research environment operating at an international level and various opportunities to broaden your expertise.
Compensation and benefits
Compensation
3000 euros brut per month according to experience
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR7241-FEKSEL-012 |
|---|---|
| CN Section(s) / Research Area | Molecular and cellular neurobiology, neurophysiology |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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