Missions

As part of a research project at the interface of chemistry and biology in the treatment of viral infections, the research assistant will work in the context of a national collaborative project to synthesize new prodrugs that will be evaluated as new vectorization tools for targeting flavivirus-associated neuroinvasive infections with nucleoside analogues.
The research assistant's tasks involve implementing and leading organic molecule synthesis methods as part of a PEPR (Programme et Equipements Prioritaires de Recherche) project, funded by France 2030 and operated by the ANR, within an interdisciplinary consortium made up of 7 teams. Appropriate synthesis and purification techniques will be implemented for the various synthesis procedures. The research assistant will have to report on the results of the syntheses carried out, and ensure regular transmission of results by writing technical reports. He/she will also carry out bibliographical research in the field to update his/her knowledge, propose efficient synthesis protocols and ensure a scientific and technological watch. (Initial contract of 12 months, renewable).

Activités

The research assistant will be responsible for researching, designing and developing new chemical synthesis techniques adapted to the aims of the project under study. He/she may also participate in the elaboration and management of the research project by proposing synthesis strategies to be implemented. He/she may advise on and take part in the laboratory's technical activities (joint tasks, experiments, traceability of manipulations and samples). He/she will be involved in bibliographical research on an ad hoc basis, and regularly in report writing.

Compétences

Holder of a BTS, DUT in organic synthesis or a professional Licence. Applications from recent Masters graduates will also be considered.
General, theoretical or disciplinary knowledge:
- Good knowledge of the main techniques for synthesising, purifying and characterising molecules.
- Fluency in English is desirable
Operational skills:
- Ability to implement operating protocols for organic synthesis (batch synthesis of a few mg to a few grams).
- Knowing how to use specific synthesis and purification equipment (ozone generator, rotary kiln, Puriflash, etc.).
- Know how to use standard analysis equipment and interpret analytical data (NMR, IR, MS, UV, etc.).
- Use expert software in the fields of bibliography and analytical data processing (NMR, IR, MS, UV, etc.)
- Know how to interpret analytical data
- Thorough knowledge of health and safety regulations and good laboratory practice).
Personal skills :
- Good work organisation and responsiveness
- Good interpersonal skills and ability to interact with colleagues
- Be rigorous and methodical
- Taking the initiative while remaining accountable
- Ability to meet deadlines and work schedules
- Respect confidentiality obligations

Contexte de travail

The research assistant will report to the Unit Director and will work in collaboration with researchers in the research unit. The research assistant will interact closely with the various staff working in the laboratory, whether in analysis or synthesis.

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.