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Portail > Offres > Offre UMR5558-NATARB-015 - Post-doctorant.e (H/F) sur létude de la contribution des chromosomes sexuels aux différences de longévité et de sénescence entre les sexes chez les mammifères et les oiseaux

Post-Doctoral position (M/F) Study of the contribution of sex chromosomes on sex differences in longevity and ageing in mammals and birds

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : jeudi 20 mai 2021

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General information

Reference : UMR5558-NATARB-015
Workplace : VILLEURBANNE
Date of publication : Thursday, April 29, 2021
Type of Contract : FTC Scientist
Contract Period : 24 months
Expected date of employment : 1 July 2021
Proportion of work : Full time
Remuneration : between 2648 and 3805 € gross monthly depending on experience
Desired level of education : PhD
Experience required : Indifferent

Missions

A post-doctoral research project supervised by Jean-François Lemaître and Jean-Michel Gaillard on the evolution of sex differences in longevity and ageing is available at the Biometry and Evolutionary Biology Lab in Lyon (https://lbbe.univ-lyon1.fr/). This project will be performed in close collaboration with two other members of the host laboratory: Gabriel Marais and Cristina Vieira, and will be funded by the ANR project LongevitY.
The aim of this project is to quantify the contribution of sex chromosome to the direction and magnitude of the differences in longevity and ageing between males and females, in mammals and birds.

Activities

The recruited post-doc will first complete a comprehensive database compiling age- and sex- specific mortality data in birds (accurate data in mammals are already available). Once age- and sex-specific mortality data will be available for both vertebrate classes, she/he will obtain accurate sex-specific estimates of lifespan, age at the onset of actuarial senescence and rate of actuarial senescence to assess the magnitude of sex-differences in ageing. As lifespan corresponds to a successive series of conditional probabilities of survival from one-time step to the next until death is reached, the understanding of lifespan variation will include a mechanistic analysis of mortality risk and its changes over ages. She/he will perform the most recent demographic analyses of life history trajectories to assess potential sex differences in the critical age classes. Additional data on sex chromosome and autosome sizes for avian and mammalian species for which lifespan and aging metrics are available will be extracted from the literature. The post-doc will then test for an association between sex-differences in lifespan and ageing, and sex chromosome heteromorphy using phylogenetically-controlled comparative analyses. Complementary fine-scale analyses using genomic data (e.g. using species-specific data on the transposable element content) will also be performed.

Skills

A solid background in at least one of the following areas (preferably several) is required: evolutionary biology, demography, biogerontology and genomics. In addition, experience with phylogenetically-controlled comparative analyses would be highly appreciated.

Work Context

The post-doc will be located in the Evolutionary Demography Team of the Biometry and Evolutionary Biology Laboratory (LBBE). The LBBE laboratory is a highly interdisciplinary research center bringing together 14 research teams and nearly 100 researchers investigating questions in evolutionary genomics, population genetics, behavioral ecology, epidemiology, parasitology, public health, medicine, biostatistics and evolutionary demography.

Additional Information

For further information, please contact either JF Lemaître (jean-francois.lemaître@univ-lyon1.fr) or JM Gaillard (jean-michel.gaillard@univ-lyon1.fr).

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