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Reference : UMR5075-MARWEI-001
Workplace : GRENOBLE
Date of publication : Thursday, November 21, 2019
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 January 2020
Proportion of work : Full time
Remuneration : 2617 - 3729 € gross monthly
Desired level of education : PhD
Experience required : 1 to 4 years
Studying the structural dynamics of acetylcholinesterase by serial X-ray crystallography to better understand its mode of action and its interaction with ligands
Enzyme crystallogenesis; collection of classic and serial X-ray diffraction data; data processing, structure solution
- crystallizing proteins
- Carry out classic and serial X-ray crystallography at synchrotrons and at XFELs
- possess basic knowledge on acetylcholinesterase and its mode of action
- have team spirit and a rigorous scientific attitude
The research will be conducted in the DYNAMOP group at the Institut de Biologie Structurale (IBS)in Grenoble. The IBS is a mixed research unit (UMR 5075) jointly operated by two French national research agencies (the CEA and the CNRS) and the University Grenoble Alpes (UGA). The mission of the IBS is to develop research in integrated structural biology to address questions in basic and applied science. The research themes at IBS are organized in three programs with multiple interactions between the different programs to foster collaboration within the IBS research groups, including the DYNAMOP group that the scientist will join. The proposed research will make use of synchrotron radiation produced at the nearby ESRF.
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