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M/F Design and Optimization of On-Chip Electrochemical DNA Synthesis Sites for Molecular Data Storage

This offer is available in the following languages:
- Français-- Anglais

Date Limite Candidature : mardi 22 juillet 2025 23:59:00 heure de Paris

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Informations générales

Intitulé de l'offre : M/F Design and Optimization of On-Chip Electrochemical DNA Synthesis Sites for Molecular Data Storage (H/F)
Référence : UPR8001-NICCLE-003
Nombre de Postes : 1
Lieu de travail : TOULOUSE
Date de publication : mardi 1 juillet 2025
Type de contrat : CDD Doctorant
Durée du contrat : 36 mois
Date de début de la thèse : 1 octobre 2025
Quotité de travail : Complet
Rémunération : 2200 gross monthly
Section(s) CN : 08 - Micro et nanotechnologies, micro et nanosystèmes, photonique, électronique, électromagnétisme, énergie électrique

Description du sujet de thèse

Within the framework of the PEPR MolecularXiv program, which aims to develop breakthrough technologies for large-scale data storage in DNA, localized synthesis on CMOS chips via electrochemical pH modulation is emerging as a particularly promising approach. This strategy enables highly scalable integration with unprecedented parallelization potential, paving the way for synthesis platforms containing several million individually addressable sites.
The proposed PhD project is positioned within this strategic context and aims to explore and design optimal electrochemical DNA synthesis sites compatible with monolithic integration on CMOS circuits. The research will focus on the geometric and functional design of electrodes (micro vs. nano, planar vs. 3D architectures), as well as on the physical and electrochemical phenomena associated with the generation of localized pH gradients. Particular attention will be given to ensuring compatibility with cleanroom fabrication processes for future co-integration with CMOS electronics, to understanding the interfacial chemistry at the heart of these disruptive devices, and to investigating the novel effects that arise at very small scales, as well as the optimal conditions for DNA synthesis.
This is a highly interdisciplinary topic at the crossroads of micro/nanofabrication, applied electrochemistry, bioelectronic interface engineering, and analytical chemistry. The PhD candidate will work in a cutting-edge research environment and collaborate closely with teams specialized in DNA chemistry, CMOS design, and technological integration.

Contexte de travail

LAAS-CNRS is one of France's leading laboratories specializing in micro- and nano-fabrication, equipped with a state-of-the-art cleanroom facility. The PhD candidate will be trained in this high-level research environment, working in close collaboration with the platform's engineering staff. The developed devices will then be packaged and electrochemically characterized using specialized equipment (notably potentiostats), in a microfluidic environment and aqueous media.
This research will also take place within the framework of a close international collaboration with LIMMS (Laboratory for Integrated Micro Mechatronic Systems), a joint CNRS–IIS laboratory located at the University of Tokyo, renowned for its expertise in nanoelectrochemistry and DNA chemistry. The project will be conducted in direct and continuous collaboration with this Tokyo-based team.

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.

Contraintes et risques

A several-month stay in Tokyo is planned as part of the PhD program.