Description of the thesis topic

Within the framework of the PEPR MolecularXiv program, which aims to develop breakthrough technologies for large-scale data storage in DNA, localized synthesis on CMOS chips via electrochemical pH modulation is emerging as a particularly promising approach. This strategy enables highly scalable integration with unprecedented parallelization potential, paving the way for synthesis platforms containing several million individually addressable sites.
The proposed PhD project is positioned within this strategic context and aims to explore and design optimal electrochemical DNA synthesis sites compatible with monolithic integration on CMOS circuits. The research will focus on the geometric and functional design of electrodes (micro vs. nano, planar vs. 3D architectures), as well as on the physical and electrochemical phenomena associated with the generation of localized pH gradients. Particular attention will be given to ensuring compatibility with cleanroom fabrication processes for future co-integration with CMOS electronics, to understanding the interfacial chemistry at the heart of these disruptive devices, and to investigating the novel effects that arise at very small scales, as well as the optimal conditions for DNA synthesis.
This is a highly interdisciplinary topic at the crossroads of micro/nanofabrication, applied electrochemistry, bioelectronic interface engineering, and analytical chemistry. The PhD candidate will work in a cutting-edge research environment and collaborate closely with teams specialized in DNA chemistry, CMOS design, and technological integration.

Work Context

LAAS-CNRS is one of France's leading laboratories specializing in micro- and nano-fabrication, equipped with a state-of-the-art cleanroom facility. The PhD candidate will be trained in this high-level research environment, working in close collaboration with the platform's engineering staff. The developed devices will then be packaged and electrochemically characterized using specialized equipment (notably potentiostats), in a microfluidic environment and aqueous media.
This research will also take place within the framework of a close international collaboration with LIMMS (Laboratory for Integrated Micro Mechatronic Systems), a joint CNRS–IIS laboratory located at the University of Tokyo, renowned for its expertise in nanoelectrochemistry and DNA chemistry. The project will be conducted in direct and continuous collaboration with this Tokyo-based team.

The position is located in a sector under the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival is authorized by the competent authority of the MESR.

Constraints and risks

A several-month stay in Tokyo is planned as part of the PhD program.