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PhD Student in Biochemistry and Cell Biology (M/F)

This offer is available in the following languages:
- Français-- Anglais

Application Deadline : 31 October 2025 00:00:00 Paris time

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General information

Offer title : PhD Student in Biochemistry and Cell Biology (M/F) (H/F)
Reference : UMR9198-CHRLEC-004
Number of position : 1
Workplace : GIF SUR YVETTE
Date of publication : 01 August 2025
Type of Contract : FTC PhD student / Offer for thesis
Contract Period : 36 months
Start date of the thesis : 1 October 2025
Proportion of work : Full Time
Remuneration : 2200 gross monthly
Section(s) CN : 22 - Cellular biology, development, evolution-development, reproduction

Description of the thesis topic

Collective cell migration plays a key role in morphogenesis, tissue regeneration, and cancer. It relies on the exchange of signals that allow cells to coordinate their speed and direction. This project aims to elucidate the molecular mechanisms that regulate the propagation of these signals through the cytoskeleton, adherens junctions between cells, and focal adhesions to the extracellular matrix. To achieve this, an in vitro system composed of purified proteins will be developed to reconstitute the transmission of mechanical and biochemical signals within a cell cohort. The mechanisms identified in this system will then be validated in a model of collective cell migration.

Work Context

The PhD will be carried out at the Institute for Integrative Biology of the Cell (I2BC), specifically within the Cytoskeleton Dynamics and Motility team of the Cell Biology Department. The I2BC is a joint research unit affiliated with Université Paris-Saclay, the CEA, and the CNRS. The PhD student will be awarded a doctoral degree from Université Paris-Saclay.

Constraints and risks

This position does not require on-call availability, involves minimal travel, and presents no specific occupational hazards.