General information
Offer title : PhD Student in Biochemistry and Cell Biology (M/F) (H/F)
Reference : UMR9198-CHRLEC-004
Number of position : 1
Workplace : GIF SUR YVETTE
Date of publication : 01 August 2025
Type of Contract : FTC PhD student / Offer for thesis
Contract Period : 36 months
Start date of the thesis : 1 October 2025
Proportion of work : Full Time
Remuneration : 2200 gross monthly
Section(s) CN : 22 - Cellular biology, development, evolution-development, reproduction
Description of the thesis topic
Collective cell migration plays a key role in morphogenesis, tissue regeneration, and cancer. It relies on the exchange of signals that allow cells to coordinate their speed and direction. This project aims to elucidate the molecular mechanisms that regulate the propagation of these signals through the cytoskeleton, adherens junctions between cells, and focal adhesions to the extracellular matrix. To achieve this, an in vitro system composed of purified proteins will be developed to reconstitute the transmission of mechanical and biochemical signals within a cell cohort. The mechanisms identified in this system will then be validated in a model of collective cell migration.
Work Context
The PhD will be carried out at the Institute for Integrative Biology of the Cell (I2BC), specifically within the Cytoskeleton Dynamics and Motility team of the Cell Biology Department. The I2BC is a joint research unit affiliated with Université Paris-Saclay, the CEA, and the CNRS. The PhD student will be awarded a doctoral degree from Université Paris-Saclay.
Constraints and risks
This position does not require on-call availability, involves minimal travel, and presents no specific occupational hazards.