Description du sujet de thèse

Description of the PhD topic:
Today, synthetic polymers play an increasingly important role in biomedical applications, from tissue engineering to surface materials and nanomedicine. The use of biomaterials in these different fields requires the development of increasingly complex architectures, meeting the following criteria: (i) biocompatibility, (ii) controlled structure and, in many cases, (iii) biodegradability.
Over the past fifteen years, the development of controlled radical polymerization has opened up incredible prospects for the relatively simple synthesis of highly controlled, yet functionalizable macromolecules, making them ideal candidates for this type of application. However, the development of biodegradable materials using these techniques remains a challenge.
In recent years, however, there has been renewed interest in the ring-opening radical polymerization (rROP) of biodegradable precursor monomers.

In this thesis project, we aim to develop innovative strategies for synthesizing rROP-degradable polymers with different degradation modalities.

Expected skills:
The candidate must hold a Master 2 in organic or macromolecular or medicinal chemistry, or an engineering degree, with a solid grounding in formulation and pharmacology/drug delivery/nanomedicine. He/she must be highly motivated and creative, and have solid practical experience of laboratory research. An excellent level of English (written/oral) is essential.

Interested candidates should provide a detailed CV mentioning training/experience, practical and theoretical skills and a full list of publications (if any), a covering letter, and the contact details of at least one academic referee - preferably two or three.

Contexte de travail

The project will be developed within the framework of a ANR project obtained in 2025

The PhD thesis will be carried out at the Institut Galien Paris-Saclay (Orsay, campus du Moulon, https://www.institut-galien.universite-paris-saclay.fr/), on the new campus of the Université Paris-Saclay, in the new Henri Moissan building, and will benefit from a first-rate academic and research infrastructure, while evolving in a rich and scientifically stimulating environment. The IGPS is a joint research unit (UMR 8612) of the CNRS and the Université Paris-Saclay, developing original and innovative research in the fields of micro- and nanotechnologies applied to drugs and diagnostics in the healthcare sector.

The thesis will be supervised by Dr. Julien NICOLAS (https://julien-nicolas.cnrs.fr/)

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.

Contraintes et risques

Working in chemistry laboratories