Informations générales
Intitulé de l'offre : PhD "Endoscopic Probe for Early In Vivo Detection of Gastrointestinal Cancer Using Stimulated Raman Histology" (M/F) (H/F)
Référence : UMR8523-ALEKUD-007
Nombre de Postes : 1
Lieu de travail : VILLENEUVE D ASCQ
Date de publication : lundi 19 mai 2025
Type de contrat : CDD Doctorant
Durée du contrat : 36 mois
Date de début de la thèse : 1 septembre 2025
Quotité de travail : Complet
Rémunération : 2200 gross monthly
Section(s) CN : 04 - Physique des atomes, molécules et plasmas. Optique et lasers
Description du sujet de thèse
Endoscopic Probe for Early In Vivo Detection of Gastrointestinal Cancer Using Stimulated Raman Histology
Contexte de travail
Endoscopic techniques are essential in the diagnosis, staging, and treatment of epithelial cancers. For many types of cancer, they are the only option for direct access to the tumor site for treatment. However, in numerous cases, precancerous tissues may exhibit subtle changes that are impossible to detect visually. Cancer detection via endoscopy thus suffers from several major limitations: (1) the commonly used fluorescent markers have limited sensitivity, and (2) the need for tissue sampling (biopsy) and in-depth analysis (histology) delays surgery and decision-making.
The goal of this thesis project is to develop a miniature probe capable of performing stimulated Raman histology to provide real-time tissue imaging in near-perfect alignment with conventional histology (hematoxylin and eosin staining). This would facilitate early and minimally invasive detection of gastrointestinal cancer and represent a substantial advancement in its treatment. Here, we propose a completely novel approach that combines the latest stimulated Raman scattering (SRS) microscopy techniques with cutting-edge technologies for assembling fiber-based miniature probes and the latest innovations in high-resolution 3D glass additive manufacturing to enable 'forward' detection of the SRS signal. This will be the first SRS endoscope capable of real-time Raman histology.
The approach of this project is broadly applicable to all types of cancer that benefit from endoscopic investigations or portable probes, and more generally to any tissue diagnosis requiring histological data, so the advances of the project will benefit numerous medical and biological applications that will be investigated in collaboration with practitioners during the PhD.
Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.
Contraintes et risques
NA