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PhD position in Metabolism and cell fate in neurogenesis

This offer is available in the following languages:
Français - Anglais

Date Limite Candidature : mercredi 22 septembre 2021

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General information

Reference : UMR8197-NATBOI-086
Workplace : PARIS 05
Date of publication : Wednesday, September 1, 2021
Scientific Responsible name : Xavier MORIN
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 October 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

The "Cell Division and Neurogenesis" team is recruiting a PhD student to study the link between metabolic regulation, mitochondrial dynamics and cellular fate choices during early neurogenesis in vertebrates. Using the spinal neural tube of the chicken embryo as a model, the candidate will develop live imaging approaches to describe the state and evolution of parameters related to cell metabolism in neural progenitors at the time of the neurogenic transition. He/she will perform gain- and loss-of-function experiments on candidate genes that regulate the variations identified during development, in order to describe their developmental consequences

Work Context

The Institut de biologie de l'ENS (IBENS) is a fundamental research center that conducts original research aimed at deciphering the fundamental mechanisms at the heart of biological processes.
A joint ENS-CNRS-INSERM unit, IBENS hosts more than 300 people grouped into 30 autonomous teams conducting highly collaborative and multidisciplinary research that combines experimental and theoretical approaches.
The research activity covers various thematic fields: Neurosciences, Developmental Biology, Functional Genomics, Ecology and Evolutionary Biology.

The host lab « Cell Division and Neurogenesis » led by Xavier Morin studies the mechanisms that control fate decisions, and specifically the choice of vertebrate neural progenitors to proliferate or to stop dividing and differentiate during the early stages of embryonic development

The École Normale Supérieure is a renown public higher education and research institution, located in the Latin Quarter in the center of Paris, close to numerous public transportation options (RER, subway, bus) and in a very nice and student area.

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