PhD student M/F
New
- FTC PhD student / Offer for thesis
- 36 mounth
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Institut Cochin
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
75014 PARIS 14
Contract Duration
36 mounth
Date of Hire
01/10/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 24 April 2026 23:59
Job Description
Thesis Subject
Mammalian cells must recycle membranes and nutrients after degradation in lysosomes to maintain homeostasis and conserve resources. This recycling activity is particularly crucial in phagocytic cells, where engulfed material is degraded and reused rather than expelled. Phagocytosis, a receptor-mediated internalization and digestion of objects larger than 0.5 microns, leads to the formation of a phagosome that matures through a series of fusion and fission with the endosomal compartments to generate a phagolysosome. This implies important remodeling of the phagolysosome, with fragmentation and fission steps, and the resulting vesicles then replenish the pool of lysosomes, in a step called phagosome resolution. How phagolysosomes resolve however still lacks detailed characterization. While the fate of phagosomes and their internalized cargo depends on the surface receptors initially engaged, the mechanisms by which phagocytic receptors modulate phagosome terminal resolution remain poorly understood.
We will investigate these critical steps of phagosomal resolution using micron-sized lipid particles functionalized with phagocytic ligands and decorated with fluorescent tracers for pH and proteolytic activity. This design will enable innovative real-time analysis of biochemical and mechanical processes underlying phagosome maturation and resolution in living cells.
Your Work Environment
The project is supported by the 80 I PRIME (Projet de recherche inter-instituts multi-équipes) interdisciplinary CNRS programme (http://www.cnrs.fr/mi).
The PhD candidate will be co-supervised by Florence Niedergang (Team « Biology of Phagocytes, Infection and Immunity» at Institut Cochin, www.institutcochin.fr) and Jacques Fattaccioli (Institut Pierre Gilles de Gennes, CNRS, ENS Chemistry Department, Sorbonne Université), in close collaboration with Jean-Maurice MALLET and Blaise DUMAT (CNRS, ENS, Sorbonne Université).
The principal working place will be Institut Cochin, which is one of the biggest biomedical French Research Center located in the center of Paris. The other laboratories are located in Institut Pierre-Gilles de Gennes, a leading institute dedicated to microfluidics and its applications, and the Chemistry department of ENS/PSL, a top tier French university and research center.
The 3 laboratories are located in the Latin Quarter in Paris, within 15 min walking distance.
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR8104-FLONIE-006 |
|---|---|
| CN Section(s) / Research Area | Molecular and structural biology, biochemistry |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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