Informations générales
Intitulé de l'offre : CDD doctorat (M/F) (H/F)
Référence : UMR8076-ABDHAM-001
Nombre de Postes : 1
Lieu de travail : ORSAY
Date de publication : mardi 20 mai 2025
Type de contrat : CDD Doctorant
Durée du contrat : 36 mois
Date de début de la thèse : 1 octobre 2025
Quotité de travail : Complet
Rémunération : 2200 gross monthly
Section(s) CN : 16 - Chimie du vivant et pour le vivant : conception et propriétés de molécules d'intérêt biologique
Description du sujet de thèse
Targeted Degradation of Tubulin Detyrosinase for Advanced Anticancer Therapies
Contexte de travail
The Ph.D. project focuses on the development of innovative strategies for the targeted degradation of tubulin detyrosinase enzymes (VASHs/SVBP), which are involved in tumor progression. The project is based on the design of PROTACs combining medicinal chemistry, chemical biology, and cellular evaluation. The doctoral student will benefit from an outstanding interdisciplinary environment between Paris-Saclay and Grenoble, with access to state-of-the-art platforms in chemistry and biology.
Contraintes et risques
The project involves handling potentially sensitive chemical reagents and conducting biological experiments in a cellular environment. The doctoral student must strictly adhere to laboratory safety regulations and may be required to manage tight deadlines associated with biological validation steps.