General information
Offer title : Thesis in Organic Chemistry (M/F) (H/F)
Reference : UMR8038-EMMROU-004
Number of position : 1
Workplace : PARIS 06
Date of publication : 28 August 2025
Type of Contract : FTC PhD student / Offer for thesis
Contract Period : 36 months
Start date of the thesis : 3 November 2025
Proportion of work : Full Time
Remuneration : 2200 gross monthly
Section(s) CN : 12 - Molecular architectures: syntheses, mechanisms and properties
Description of the thesis topic
Total synthesis of macrocyclic quartromicins, a rare family of pseudo-C2-symmetric tetrameric spirotetronates.
These molecules exhibit remarkable antibiotic and antiviral activities. Their synthesis represents a considerable challenge due to their complex tetrameric structure and the presence of two contiguous quaternary stereogenic centers.
Work Context
UMR 8038, Faculty of Pharmacy, 4 Avenue de l'Observatoire.
C-TAC team specialized in the total synthesis of natural products, organometallic chemistry, and strategic innovation.
Equipment: 400 and 300 MHz NMR spectrometers, preparative HPLC, high-resolution mass spectrometry (Synapt and Orbitrap).
Constraints and risks
All hazards commonly associated with the handling of organic reagents.