Informations générales
Intitulé de l'offre : Phenotypic evolution in immune repertoires M/F (H/F)
Référence : UMR8023-ALEWAL-012
Nombre de Postes : 1
Lieu de travail : PARIS 05
Date de publication : mercredi 14 mai 2025
Type de contrat : CDD Doctorant
Durée du contrat : 36 mois
Date de début de la thèse : 1 septembre 2025
Quotité de travail : Complet
Rémunération : 2200 gross monthly
Section(s) CN : 01 - Interactions, particules, noyaux du laboratoire au cosmos
Description du sujet de thèse
Viruses, such as influenza, evolve under the selection of host immune systems. Previously infected individuals become immune, forcing the virus to find susceptible hosts or mutate, chasing it away in antigenic space. The goal of this project is to formulate this viral escape process in antigenic space and show how the behaviour is canalized by cross-reactivity using methods of statistical physics and nonlinear dynamics.
Contexte de travail
The student will work in the group of T. Mora and A. Walczak that works on various questions of theoretical biophysics, as well as in the broader biophysics groups at LPENS and at the ENS bio institute.
Contraintes et risques
no risks