Description du sujet de thèse

Diffuse midline gliomas (or DMGs) are incurable tumors associated with a median survival of less than one year and remain a major challenge in paediatric oncology. Their oncogenesis, linked to epigenetic dysregulation through histone H3 K27 alterations, is very specific in terms of anatomical location and associated with altered neurodevelopmental mechanisms. Our aim is to study in depth the heterogeneity and specificity of progenitors of the human hindbrain to better understand their susceptibility to this oncogenic process. The project integrates in the PEPR Cell-ID, which aims at understanding early lineage derail to identify possible strategies of cell-based disease interception.

Contexte de travail

The person recruited will conduct a doctoral thesis under the joint supervision of Pascale Gilardi and David Castel, within the “Human Neurodevelopment and Diseases” team led by Vanessa Ribes and Stéphane Nedelec at the Jacques Monod Institute (https://www.ijm.fr/research-topics/ribes-nedelec-lab-va/?lang=en) and the "Genomics and oncogenesis of childhood brain tumors" team at the gustave roussy institute (https://www.gustaveroussy.fr/en/genomics-and-oncogenesis-childhood-brain-tumors)

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.

Contraintes et risques

Work in L2 lab
possibility of shifts during weekends