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Reference : UMR7361-KARMOU-004
Workplace : MULHOUSE
Date of publication : Friday, July 17, 2020
Scientific Responsible name : Karine MOUGIN
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 September 2020
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
Development of a sensor in micro- and Nano-regenerative technologies for the detection and measurement of traces of molecules (NanoTRACES)
The thesis subject is based on an R&T type project called NanoTRAACES in progress at CNES. The aim of this project is to create a new device for detecting and measuring the concentration of specific molecules and their chirality present in the environment in the form of traces (ppt or lower). This sensor, which is based on the potential of Micro- and Nano-Technologies, constitutes a technological breakthrough which will be able to meet a growing need for in-situ analyzes by providing a miniaturized sensor that can be integrated into lab-on solutions. -chip.
The development of this device will be achieved on a nanostructured surface, made of nanoparticles (NPs) that will constitute the active part of a microsystem component integrating electrical and microfluidic functions. The device will allow selective adsorption of target molecules, regenerate after use, and deliver both qualitative and quantitative information. In-situ measurement of traces of targeted molecules has many advantages in areas such as health, biochemistry, security or space research. The modularity of the sensor, ensured by a simple modification of the functionalization of the NPs, will be exploited within the project in a specific task dedicated to the industrial development of the demonstrator.
This project will focus on the detection of traces of amino acids and their enantiomers in the space environment, in particular for the search for traces of life in an extraterrestrial environment. However, other applications are targeted such as the health field as well as all environmental applications for monitoring amino or other pollutants. The requirements related to the space environment and in-situ analysis will impose choices on the technological development of the system, whether on the performance or the reliability of the demonstrator.
The objective of this thesis is to allow the realization of the active surface of the demonstrator as well as the measurement of traces of concentration of organic molecules by electrochemical way and to compare these results with those obtained previously by coupling of chromatography and mass spectroscopy.
PhD will be carried out at IS2M in Mulhouse as a priority.
The IS2M is a joint CNRS-University of Haute-Alsace research unit (UMR 7361). Due to its multidisciplinary nature, its scientific impact and its interactions with other fields, the laboratory constitutes one of the structuring forces of the Materials landscape and their applications in the academic and industrial world, both regionally and nationally. It is made up of around 80 researchers and slightly more students.
This thesis is also in partnership with CNES in Toulouse.
Constraints and risks
No specific constraints has been identified.
The candidate must hold a master's degree in materials science or engineering, physics or chemistry. Fundamental bases in the field of interfacial phenomena (physical or physico-chemistry), in particular self-assembly phenomena, nanoparticles and nanostructures, as well as concepts in electrochemistry is recommended.
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