Description of the thesis topic

Endometriosis is a chronic disease associated with severe, life-impacting pain during menstrual periods and a high risk of infertility that affects up to 10% of women worldwide. GWAS studies have identified several candidate genes that are associated with a high risk of developing endometriosis including the Growth Regulating Estrogen Receptor Binding protein GREB1. Aim of the present project is to perform molecular studies on GREB1 and its paralogue GREB1L in the female reproductive system with a particular focus on the endometrium. You will use a combination of in vitro experiments, genetic studies in mice, and biochemical approaches to further dissect the molecular function of these genes and their roles in hormonal signalling and endometriosis. To achieve these goals, you will have access to state-of-the-art technology platforms, including dedicated microscopy infrastructure, cytometry, histology, bioinformatics and animal facilities of various model organisms.

Work Context

The Institute of Biologie Valrose (iBV) is a center of excellence funded by the CNRS, Inserm and the University Cote d'Azur (Nice) that focuses on basic principles governing organism development and mechanisms leading to diseases. The Schedl team focuses on the molecular programs driving development and maintenance of organs and their links with cancer (http://ibv.unice.fr/research-team/schedl/).