Position description PhD in Analytical Chemistry (M/F)

Job Description

Thesis Subject

Immunopeptidomics is currently one of the most promising applications of proteomic analysis. Advances in mass spectrometry instrumentation have enabled the sensitivity levels required to comprehensively identify the repertoire of immunopeptides presented by HLA molecules and purified from only a few million cells. Nevertheless, immunopeptidomics still faces major analytical challenges throughout the entire workflow, ranging from the biochemical steps involved in the sensitive and contamination-free purification of immunopeptides, to the adaptation of chromatographic separation and tandem mass spectrometry sequencing methods for these particular peptides (non-tryptic peptides), and finally to the implementation of appropriate data-processing strategies.
The candidate will be involved in optimizing all of these steps and will apply the optimized methods to characterize immunopeptidomes and identify neoepitopes in the context of lymphoid malignancies

Your Work Environment

The PhD will be attached to the Doctoral School of Chemical Sciences of the University of Strasbourg (ED222).

The IPHC, a joint research unit jointly supervised by the CNRS and the University of Strasbourg (UMR7178), is a multidisciplinary laboratory where research teams from different scientific backgrounds (ecology, physiology and ethology, chemistry, and subatomic physics) develop high-level research programs based on scientific instrumentation. The IPHC is organized into three departments and has a total staff of 393 employees (M/F), including 257 permanent staff (119 researchers and faculty members and 138 engineers and technicians, M/F), 46 employees on fixed-term contracts, and 102 doctoral students (M/F).
The PhD student will join the LSMBO (Laboratory of Bioorganic Mass Spectrometry) team at the IPHC, which consists of 12 researchers and faculty members and 9 permanent engineers and technicians (M/F)
The PhD student will join the LSMBO team of IPHC and will benefit from all the material conditions (LC-MS / MS instrumentation), human support (sharing of expertise) and IT (access to all the software tools for the processing of LC-MS / MS data) necessary for the successful completion of this thesis project.
The PhD project will be conducted in close collaboration with clinical hematologist-oncologists at the Strasbourg University Hospitals (Dr. Delphine Rolland and Prof. Luc Fornecker), as well as with academic and industrial partners already identified for projects requiring immunopeptidomics-based approaches.
The candidate must hold a master's and/or engineering degree.
He/she will need to prove a solid knowledge of protein biochemistry, in mass spectrometry and chomatography. A strong interest for bioinformatics and data processing will be an advantage.
The candidate must have a good command of written and spoken English at level B2 according to the Common European Framework of Reference for Languages to be able to report regularly and present his/her results to the collaborators and at conferences.

Applications should include a detailed CV, a letter of motivation, a summary of the Master's thesis as well as the grades of Master 1 and 2.

Constraints and risks

-Casual work in staggered schedule
-Work in an ISO 9001 certified environment

Compensation and benefits

Compensation

2300 € gross monthly

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions