General information
Offer title : PhD student in Bioinformatics (M/F) (H/F)
Reference : UMR5535-SARADE-082
Number of position : 1
Workplace : MONTPELLIER
Date of publication : 06 September 2025
Type of Contract : FTC PhD student / Offer for thesis
Contract Period : 36 months
Start date of the thesis : 1 October 2025
Proportion of work : Full Time
Remuneration : 2200 gross monthly
Section(s) CN : 27 - Host-pathogen relationship, immunology, inflammation
Description of the thesis topic
Type I interferonopathies are a group of rare genetic diseases in which the immune system is chronically activated due to excessive production of type I interferons. This leads to chronic inflammation and damage affecting multiple organs. Although these diseases are primarily associated with immune system dysfunction, recent research suggests that changes in metabolism, particularly lipid processing, may also play a key role in their development.
The thesis project will explore the relationship between immune activation and metabolism in type I interferonopathies within tissues. Using mouse models of these diseases, we will analyze how metabolic alterations contribute to inflammation and tissue damage. We will generate lipidomic and transcriptomic data that will be subjected to bioinformatic analysis to integrate and interpret complex datasets, helping us to better understand the underlying mechanisms of the disease.
Our results should provide insight into how inflammation and metabolic imbalances affect tissue homeostasis in type I interferonopathies.
Work Context
The student will be supervised by Nadine Laguette (Institute of Molecular Genetics of Montpellier – IGMM, Montpellier).
The Institute of Molecular Genetics of Montpellier (IGMM) is a joint research unit of the CNRS and the University of Montpellier, composed of 207 staff members, organized into 18 research groups, 9 core facilities (including 5 shared with other units on the CNRS campus), and 9 scientific and technological platforms.
IGMM is a multidisciplinary institute, and its research in molecular and cellular biology has a strong international impact, both fundamental and applied.
For more information: www.igmm.cnrs.fr
We are looking for a motivated and dynamic student with solid knowledge in completed: ........, and a strong interest in inflammation-related topics and associated molecular mechanisms.
Further information about the host team: https://www.igmm.cnrs.fr/team/bases-moleculaires-de-linflammation/
Constraints and risks
- Working hours may vary (evening and/or weekend work possible)