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Reference : UMR5255-MIRBLA-001
Workplace : TALENCE
Date of publication : Tuesday, April 27, 2021
Scientific Responsible name : Mireille Blanchard-Desce
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 1 September 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
The aim of the proposal consists in the development of anti-oncogenic therapies for more specific and efficient chemotherapies focussing on increasing the efficiency/side effects ratio. In this perspective, the candidate will develop a new approach based on (i) the use of bioinspired, organic-based nanoparticles which combine high solubility in aqueous solution (>250 g.L-1), intrinsic fluorescence and biocompatibility, preferential internalisation in cancerous cells and ease of functionalisation; (ii) their conjugation with photo-activatable caged molecules, to trigger the near-infrared irradiation induced release of cytotoxic compounds at the tumour site; (iii) the biological effects characterisation of the new prodrugs NP[(cytotoxic)cage] on physiomimetic samples.
This PhD subject relies on the synergistic and complementary interaction of two groups of the Bordeaux campus (Chemistry and Biophysics), both experienced in interdisciplinary research.
1/ The Imaging & Molecular Photonic group (IPM), that belongs to the 10-group wide Institute of Molecular Sciences of Bordeaux ('Unité Mixte de Recherche' -UMR5255- under the administrative supervision of the University of Bordeaux , the CNRS and Bordeaux INP, gathering about 250 peoples), located on the Talence campus. The IPM group has a leading expertise in the design, synthesis and characterisation of fluorescent dyes and nanoparticles for multiphoton excitation and mostly designed towards their use in biophotonics (imaging, therapeutics, sensors). The group musters all the equipment, expertise, and supervision required for the accomplishment of all the aspects of the design, the setting-ups, the study and optimization of the nanoparticles for the photo-inducible anti-cancerous therapy.
2/ The BioImaging and OptoFluidics group of the LP2N (Laboratory for Photonics, Digital and Nanosciences – UMR 5298 - under the administrative supervision of the University of Bordeaux, the Institute of Optics, Graduate School and the CNRS), located as well on the Talence campus. The group masters microfabrication and microfluidics for engineering hollow sphere encapsulation of organoids and spheroids, to study cell behaviours in confined environment, and uses biophysical approaches to measure, quantify and monitor these behaviours in time. All the methods are of routine use in the lab.
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