Faites connaître cette offre !
Reference : UMR5247-VINDAR-003
Workplace : MONTPELLIER
Date of publication : Tuesday, November 17, 2020
Scientific Responsible name : Vincent Darcos
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 11 January 2021
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly
Description of the thesis topic
ENT cancers rank 5th in France in terms of incidence with more than 7500 new cases of cancer of the oral cavity in France every year. More than 70% of patients with cancer of the oral cavity or oropharynx benefit from radiotherapy treatment. Osteoradionecrosis is a late and severe complication of radiotherapy and its incidence is estimated at 10%.
The objective of this PhD project is the development of a porous, pro-angiogenic and antibacterial organic-inorganic composite for bone reconstruction following osteoradionecrosis (size of bone defects greater than 1 cm). The customised functionalisation of inorganic bioactive glass particles by degradable polymers such as poly(lactic acid) will be coupled with the "freeze-casting" process (directed freezing for the generation of porosity) to allow fine control of the properties of the final nanocomposite. The effect of different parameters (type of particles, nature and functionalisation of the polymers, grafting rate, solvent, temperature gradient, etc.) on the porosity (organisation, size) and on the physico-chemical and biological properties of the bone substitute will be studied.
The methodology that will be followed during this thesis aims at establishing a link between the composition and multi-scale structure of these porous materials on the one hand and their physico-chemical and biological properties on the other hand. It includes the following main steps: 1) Synthesis and characterisation of bioactive glass nanoparticles and (co)polymers, 2) Functionalisation of mineral nanoparticles with the polymer (core-shell particles), 3) Elaboration of porous nanocomposite scaffolds by freeze-casting, 4) Study of the porosity and mechanical properties of the material, 5) Study of the physico-chemical degradation mechanisms in vitro, 6) Evaluation of the biological properties in vitro (cytocompatibility and antibacterial behaviour).
This multidisciplinary thesis will be part of the CongOs project (2021-2025) funded by the French National Research Agency (ANR). It will rely on a consortium of five academic partners and one industrial partner, with complementary areas of skills and expertise (polymer chemists, materials chemists, biologists, surgeons, R&D engineers).
The thesis will take place partly in the IBMM Artificial Biopolymers team in Montpellier (http://ibmmpolymerbiomaterials.com) and in the Phosphates, Pharmacotechnics, Biomaterials team of the CIRIMAT in Toulouse (http://www.cirimat.cnrs.fr/spip.php?rubrique24).
We talk about it on Twitter!