Description du sujet de thèse

ADVANCED 4D BIOMATERIALS FOR MUCOSA AND SUB-MUCOSA TREATMENT IN PATIENTS AFFECTED BY INTESTINAL DISEASES (Daedalus)
financed by the EU program HORIZON EUROPE

4D biomaterials enable new surgical treatments by autonomously acting in response to environmental stimuli, thus overcoming the limitations of standard medical strategies. DAEDALUS is a European project that gathers 13 partners and has the ambitious goal to develop two advanced 4D composite biomaterials designed to facilitate the re-epithelization of the colorectal mucosa and submucosa after their removal.

In the frame of this consortium, a PhD position is opened in the in the Department of Polymers for Health and Biomaterials (PHBM) of the Institute of Biomolecules Max Mousseron (IBMM) in Montpellier-France, under the supervision of Pr. Benjamin Nottelet. PHBM has extensive experience in the domain of degradable polymers for medical devices and controlled release systems.

In more details, the PhD project is dedicated to the development of multifunctional star-shaped and photo-crosslinkable polyether-polyester degradable copolymers that will be associated with gelatin derivatives to produce biomaterials suitable for 3D-printing. As a function of the targeted tissue to be replaced (mucosa or submucosa) the copolymers will be designed and functionalized to ensure specific properties (self-healing, interactions with magnetic SPIONs, bio-adhesion etc..) compatible with the 4D properties targeted in DAEDALUS.

In this PhD, you will be in charge of developing and characterizing the polymers and their formulations. The tasks will be divided as follows:
- synthesis of degradable photocurable polymers for hydrogels and for elastomers
- formulation of photoresins for 3D printing
- evaluation of the polymers and networks properties
- evaluation of the biocompatibility
- evaluation of the degradation

Due to the nature of the project, you will demonstrate a strong ability to interact with European partners and to coordinate your project with other PhDs and scientists of the consortium.

The position will start in fall 2025, ideally in September/October 2025.

Keywords: Implantable medical device, degradable elastomers, degradable hydrogels, polymer chemistry, advanced 4D properties

Skills: polymer chemistry, macromolecular engineering and process, materials science, english, communication

Duration and location: 3 years, IBMM-Polymers for Health and Biomaterials, Montpellier, FR

Supervisor and contact: Pr. Benjamin Nottelet Benjamin.Nottelet@umontpellier.fr

Please send your detailed CV, marks from the last two years of studies and at least two emails of reference persons.

Contexte de travail

Department of Polymers for Health and Biomaterials (PHBM) of the Institute of Biomolecules Max Mousseron (IBMM) in Montpellier-France
https://ibmm.umontpellier.fr/polymeres-pour-la-sante-et-biomateriaux/

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.