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Subcortical networks role in motor and behavioral compensation after stroke: Study combining behavioral analysis and multimodal brain imaging in non-human primates. (M/ W)

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Français - Anglais

Date Limite Candidature : mercredi 6 juillet 2022

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General information

Reference : UMR5229-LEOTRE-005
Workplace : BRON
Date of publication : Wednesday, June 15, 2022
Scientific Responsible name : Léon Tremblay
Type of Contract : PhD Student contract / Thesis offer
Contract Period : 36 months
Start date of the thesis : 3 October 2022
Proportion of work : Full time
Remuneration : 2 135,00 € gross monthly

Description of the thesis topic

This thesis aims to determine the involvement of subcortical structures, mainly the striatum and thalamus as well as the fiber networks or connections between these structures and the cerebral cortex, in the compensation phenomena that occur after stroke and which allow motor and behavioral recovery of animals. The PhD student will be in charge of carrying out the experiments and the follow-up of the animals which will have a stroke by occlusion of the middle cerebral artery, a model established by Dr Canet-Soulas, co-director of this research project thesis. He or she will be responsible for the daily training of the PNHs involved in the project and, this during the three months preceding stroke and after during the following months, when the phenomena of recovery appears. He/she will also be responsible for the acquisition and processing of behavioral data, which will be correlate with PET-MRI imaging acquisitions to determine the striatal and thalamic territories involved in behavioral recovery. The doctoral student will be responsible for carrying out the analysis of the results to lead them to the writing and publication of one or two scientific articles.

The ideal candidate must possess:
- Knowledge of the brain anatomy of animal and/or human,
- Knowledge of the cerebral networks of motor control and behavioral adaptation,
- Skills to work with animals, ideally with a level 1 for animal experimentation,
- Disposition to teamwork and be regular and well organized allowing to do collaborative work.
- Fluency in written English.

Work Context

Tremblay's team, named "Pathophysiology of Basal Ganglia" is specialized in the study of neurological (Parkinsons disease, Tourette's syndrome) and psychiatric disorders (impulsivity, anxiety and anorexia) resulting from dysfunctions of these subcortical structures. This team, led by Dr Tremblay, has clearly demonstrated the involvement of these subcortical structures in the compensation mechanisms following a degenerative process, induced by MPTP intoxication in the PNH model of Parkinson's disease. This team is part of the "Institut des Sciences Cognitives Marc Jeannerod" (ISCMJ) which is located on Vinatier site, in Bron. This laboratory has access to the CERMEP brain imaging platform, located a 5-minute walk from the Institute. It is on this imaging platform that multimodal imaging acquisitions will be carried out, on one of the rare hybrid cameras that can simultaneously perform acquisitions by Positron Emission Tomography (PET) and functional MRI.

This project on Behavioral Neurosciences and the neural bases of post-stroke compensation mechanisms is carried out as part of a translational and collaborative research project, including a clinical component in stroke patients, carried out by the CarMen-IRIS team. The project is funded by the National Research Agency (ANR) for 4 years, making it possible to carry out this thesis project over 3 years of studies leading to "PhD in Cognitive Neurosciences". This is a codirected thesis project between Dr. Tremblay and Dr. Canet-Soulas, a specialist in cerebral ischemia and imaging markers of cerebrovascular activity (blood flow, oxygen consumption, etc.) and post-stroke inflammatory processes. Dr. Canet-Soulas created this unique ischemia model on NHP. Dr Tremblay's team is part of the ISCMJ, which encourages interaction and collaboration between research teams, with weekly seminars, several social activities and scientific exchanges on the Neurosciences of normal and pathological behaviors. The scientific reputation and the level of the research works of Dr. Tremblay's team and his colleagues make the ISCMJ a center of excellence for research and the training of students working at the interface of fundamental research and clinical application to neurological disorders.

Constraints and risks

PET imaging involves injections of radioactive tracers, injected on the animals at low dose without risk for the experimenter. However, the PhD student will be checked for their exposure level to radioactivity during each scan.

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