Description du sujet de thèse

The central tenet of NeutroFLAME project is to study and characterize the unexpected function of the NADPH oxidase in neutrophils as a central break of caspase-1-dependent pyroptosis and to model the subsequent dysregulated inflammation observed in Chronic granulomatous diseases (CGD) patients during infection.

Contexte de travail

The primary objective of the Institute of Pharmacology and Structural Biology (IPBS-Toulouse) is the identification, characterization, and exploitation of new therapeutic targets in the fields of cancer, infection, and inflammation. These discoveries are achieved through the use of molecular and cellular biology approaches, as well as in vivo experiments. Within the IPBS, the Inflame team, led by Dr. Etienne Meunier, studies the mechanisms of pathogen detection and elimination for the discovery of new antimicrobial targets and the identification of new therapeutic or vaccine strategies. The position is located in a relevant sector of the Protection of Scientific and Technical Potential (PPST), and therefore requires, in accordance with regulations, that your arrival be authorized by the competent authority of the MESR.

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.

Contraintes et risques

Handling of chemicals and mutagens. Personnel will be required to work in biosafety level 2 and 3 environments for the handling of pathogenic bacteria such as Pseudomonas aeruginosa, C. violaceum, B. cenocepaciae, S. typhimurium and the tuberculosis bacillus.