Description du sujet de thèse

This project aims to understand how physical forces within tissues and gene expression interact to shape the embryonic body during its elongation, with implications for congenital disorders such as spina bifida and caudal regression syndromes. By combining developmental biology and engineering, we will seek to quantify the distinct mechanical properties of key embryonic tissues and test their impact on cell behavior, tissue organization, and differentiation. Most importantly, the project addresses a gap in current research by investigating how mechanical forces can feed back to influence gene expression, thus revealing a complex interaction that will offer a new perspective on axial elongation and potentially contribute to the early diagnosis and prevention of congenital disorders.

Contexte de travail

This PhD project will be carried out in partnership between the Centre for Integrative Biology (CBI) in Toulouse and the LAAS-CNRS (Laboratory for Analysis and Architecture of Systems) in Toulouse. The project combines the CBI's expertise in developmental biology with the LAAS's skills in biophysical measurements to explore the interactions between mechanical forces and gene expression during embryonic axis elongation.

Contraintes et risques

no risks identified