Doctorant ou doctorante en Neurooncologie Computationnelle (M/F)
New
- FTC PhD student / Offer for thesis
- 36 months
- BAC+5
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Unité de biologie moléculaire, cellulaire et du développement
Contract Type
FTC PhD student / Offer for thesis
Working hHours
Full Time
Workplace
31062 TOULOUSE
Contract Duration
36 months
Date of Hire
02/11/2026
Remuneration
2300 € gross monthly
Apply Application Deadline : 23 September 2026 23:59
Job Description
Thesis Subject
Atypical teratoid/rhabdoid tumors (AT/RT) are aggressive pediatric tumors that arise in the central nervous system in very young children. They are caused by mutations in the SmarcB1 tumor suppressor gene, which encodes a protein in the SWI/SNF chromatin remodeling complex. AT/RT tumors are characterized by significant changes in the epigenome and cellular metabolism. The goal of this thesis project is to characterize the dynamics of epigenome evolution over time in an AT/RT model based on SmarcB1 loss-of-function coupled with metabolic alterations in human brain organoids, using integrative computational approaches. The PhD student will be responsible for preparing samples for epigenomic analyses (ATAC-Seq, Cut&Run) and performing computational analyses. He or she will be integrated into two research teams: one based at the CRCT for the computational aspect (https://www.crct-inserm.fr/annuaire/vera-pancaldi/) and the other based at the CBI for the experimental aspect (https://cbi-toulouse.fr/equipe/davy/).
We are seeking a highly motivated, independent, and meticulous candidate with a master's degree in biology or bioinformatics. Expertise in computational epigenome analysis is required, and prior experience in cell culture would be a plus, as would familiarity with modeling concepts. Fluency in English is required to present results in frame of the PEPR Cell-ID or other scientific events.
Your Work Environment
The PhD student will be co-supervised by Vera Pancaldi (CRCT INSERM) for the computational component and by Alice Davy (CBI CNRS) for the experimental component. The Center for Integrative Biology (CBI) is one of the leading centers for basic research in biology in Toulouse; it is located on the Rangueil campus of the University of Toulouse. The Toulouse Cancer Research Center (CRCT) is a major cancer research hub located on the Oncopôle campus. Both institutes are easily accessible by public transportation.
Constraints and risks
- Possibility of on-call duty for cell culture on weekends and holidays (up to one day per month)
Compensation and benefits
Compensation
2300 € gross monthly
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR5077-ALIDAV-005 |
|---|---|
| CN Section(s) / Research Area | Cellular biology, development, evolution-development, reproduction |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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