Profil Recherché

Titulaire d’un doctorat ou diplôme équivalent ou justifiant de titres et travaux scientifiques jugés équivalents par l’instance compétente de l’établissement. Il n’y a aucune condition d’âge ou de nationalité pour candidater. Tous les emplois CNRS sont accessibles aux personnes en situation de handicap en bénéficiant d’aménagement d’épreuves rendus nécessaires par la nature du handicap

Stratégie d'établissement

Chemobiology opens up a powerful methodological field for understanding the mechanisms underlying living organisms and their pathophysiological imbalances. The ambition is to strengthen the CNRS scientific excellence in this field by targeting researchers at the interface of the CNRS Chemistry and CNRS Biology, in order to develop a fundamentally interdisciplinary project. Candidates will need to demonstrate expertise in chemobiology or biological chemistry of nucleic acids or in the regulation of RNA expression, translation or stability in eukaryotes, prokaryotes or viruses.
The CNRS is committed to covering all disciplines and to being a major player in the field of health. The CNRS is in fact the only research organization that brings together all scientific disciplines, and interdisciplinary aspects will be crucial to the development of the theme of this Chair.

Stratégie du laboratoire d'accueil

We are targeting 3 laboratories on the CNRS campus in Montpellier, as well as 2 laboratories in the Paris region. These multidisciplinary campuses offer a very rich environment in terms of scientific themes in both biology and chemistry, and the CPJ will strengthen interdisciplinary collaborations between a chemistry unit and a biology unit specializing in the design and/or study of RNAs to understand how living organisms function:

- IBMM is a highly visible unit at national and international level for its work on the synthesis and modification of nucleic acids, particularly mRNA, in the study of living organisms and their malfunctions. The expertise covers the design, synthesis and analysis of natural or modified oligonucleotides for diagnostic, detection or therapeutic purposes. Research also extends to the use of nucleic acids as functional systems in biology and synthetic chemistry. Finally, bioinspired systems are designed to understand, imitate or trigger biological processes. In anticipation of the departure of 3 senior researchers in this flagship area, a short-term reinforcement of its workforce is necessary, in order to preserve this unique know-how.
- IGMM is a research unit recognized nationally and internationally for the quality of its research and the ambition of its projects, as demonstrated by the presence of 3 ERC-accredited teams. The IGMM's main areas of expertise are the study of RNA function, metabolism and maturation, gene and epigenetic regulation, immuno-oncology and viral infections. The development of biotherapeutics is also a major focus of the IGMM, with the creation of start-ups including Abivax. The IGMM is facing a renewal of its research teams. The integration of a research team specializing in chemobiology applied to RNAs will enable this biology unit's flagship themes to be strengthened by new approaches.

- IRIM is a research unit recognized nationally and internationally for the quality of its work on viral and bacterial infectious diseases. IRIM teams are developing research aimed at gaining a better understanding of the regulation of the viral cycle, in particular replication, bacterial replication and the cellular mechanisms of recognition of the nuclear acids of infectious agents. IRIM is facing a renewal of its research teams. The integration of a research team specializing in chemobiology applied to RNAs will enable this biology unit's flagship themes to be strengthened by innovative approaches.

- LCBPT is a research unit located at the Faculty of Fundamental and Biomedical Sciences of the Université Paris Cité on the Saints Pères site. The laboratory is internationally recognized for its work on RNA ligand design and nucleotide chemistry, in particular bi-substrate ligands for the study of RNA methylation.

- The Genome Integrity, RNA and Cancer unit (UMR3348) is a research unit located at Curie Orsay, a branch of the Institute Curie Research Center. This prestigious campus has a long history of promoting research in biology and chemistry. UMR3348 studies the molecular mechanisms involved in maintaining genome integrity, with a particular focus on the role of RNA and its molecular partners in cancer. In particular, the teams explore the links between RNA metabolism and genomic instability, alternative splicing and RNA-related signaling. The chair would reinforce efforts of the unit to improve understanding and fully exploit the potential of RNA in cancer research.

Stratégie Internationale

The size of the scientific community active in RNA chemobiology is currently too small to respond rapidly to the major challenges in biology and health, such as emerging infectious diseases and various pathological dysfunctions such as cancer. Regaining strength and increasing skills in this field requires not only appropriate training in universities, but also the recruitment of talented scientists who are already trained and experienced in this field. Attracting a talented young researcher, possibly trained abroad in countries that have been able to maintain this type of activity, appears to be facilitated by the CPJ scheme, which will provide a suitable environment for the laureate to begin his or her project.

Répertoire national des structures de recherche (RNSR) du laboratoire d'accueil

200711912X IBMM Institut des Biomolécules Max Mousseron
199111979P IGMM Institut de Génétique Moléculaire de Montpellier
201722408M IRIM Institut de Recherche en Infectiologie de Montpellier
199812928R LCBPT Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques
201019806P Intégrité du génome, ARN et cancer

Résumé du projet scientifique

This Junior Professorship will focus on the development of fundamental RNA research applied to the life sciences through chemobiology approaches (recently honored by the Nobel 2022 for click and bioorthogonal chemistry). Through the study of natural or engineered and modified RNAs, it should lead to new insights into how living organisms function, by intervening with precision on biological matter in order to identify, probe, target, control, repair or even eliminate it in a highly controlled manner.

Résumé du projet d'enseignement

The research theme of this CNRS Chair can be applied to the University of Montpellier and its partner institutions (ENSCM), Université Paris-Cité or Paris-Saclay. The nature of the courses taught by the laureate in one of these establishments will be in line with the needs of the establishment in terms of bachelor's and master's degrees, and will take advantage of the profile of the laureate and his or her research in RNA chemobiology to understand how living organisms function.

Environnement Financier

• Total financé (dont package ANR) : 200 k€
• Total du projet : k€

Diffusion scientifique

The dissemination of the results will be done through world-class scientific productions: publications, patents, software... In addition, the results will be communicated to various targets such as scientific communities, media, decision makers, general public, schools, etc., with an adapted calendar. Specific tools may be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.

Science ouverte

The CNRS is developing a strong policy in favor of open science. Open science consists of making research results "as accessible as possible and closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its laboratories accessible , in particular through deposit in HAL. The data produced must also be made available and reusable, except for specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, to be more qualitative and to take into account all facets of the researcher's profession.

Science et société

The relationship between science and society is now recognized as a full dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will contribute to informing public decision-making. Participatory science initiatives may be initiated with actors from the project’s socio-economic and cultural eco-system.

Indicateurs

The activity will be evaluated in particular on the basis of scientific production (publications, software, patents, etc.), on institutional and private partnerships formalized by contracts, on international presence, on the promotion of work to multidisciplinary scientific communities, on innovation and its transfer to society and on scientific dissemination to non-specialist audiences.

Modalités d'organisation des auditions

Seul(e)s seront convoqué(e)s aux auditions les candidat(e)s sélectionné(e)s sur dossier par la commission de sélection