Profil Recherché

Titulaire d’un doctorat ou diplôme équivalent ou justifiant de titres et travaux scientifiques jugés équivalents par l’instance compétente de l’établissement. Il n’y a aucune condition d’âge ou de nationalité pour candidater. Tous les emplois CNRS sont accessibles aux personnes en situation de handicap en bénéficiant d’aménagement d’épreuves rendus nécessaires par la nature du handicap

Stratégie d'établissement

Recent years have seen major advances in the fields of transcriptomics, metabolomics and proteomics. These approaches offer powerful tools for studying the molecular and cellular basis of organ function, and for better understanding organ dysfunction under pathological conditions. Integrating these heterogeneous, multi-scale data to elucidate systemic mechanisms requires the development of new approaches in computer science and mathematics. This approach, which falls within the framework of systems biology, represents an emerging and strategic field that must be strengthened at the national level to maintain the scientific leadership of CNRS Biology, both at the national and the international levels.
In 2023, under the leadership of Sagi Shapira (INEM), an internationally renowned expert in systems biology, CNRS Biologie created the “Paris Quantitative Biology Initiative” research federation which brings together teams from INEM, Imagine Institute and Pasteur Institute, with the ambition of fostering synergies between teams located on the Necker campus developing innovative approaches to systems biology. Following the departure of Sagi Shapira, Nicolas Venteclef, a researcher at INEM, is now in charge of the federation. To reinforce the scientific momentum and ensure the development of this field of excellence, it is essential to recruit new teams specialized in systems biology. With this in mind, a junior professorship will be created within INEM (UMR 8253).

Stratégie du laboratoire d'accueil

INEM is recognized nationally and internationally for the excellence of its work in human pathophysiology. This research combines first-rate fundamental research and, thanks to its proximity to Necker Hospital, top-quality translational research, focusing on metabolic syndromes, chronic diseases and immune system pathologies, whether inherited or acquired.
In recent years, INEM's research teams have initiated multi-omics studies, demonstrating their determination to strengthen these approaches by developing a strategic axis in systems biology. In order to support this development and consolidate INEM's international visibility in this fast-growing field with high strategic stakes, CNRS Biology aims to recruit a research team specialized in systems biology applied to pathophysiology or immunology for this unit.

Stratégie Internationale

Thanks to its international reputation, INEM is highly attractive to foreign researchers, post-docs and PhD students, with half of its team leaders and almost 50% of its staff coming from abroad.
INEM is also very active in European training networks, piloting the ITN TrainCKDis network, and has hosted 9 ERCs, 4 of which are ongoing.

Répertoire national des structures de recherche (RNSR) du laboratoire d'accueil

INEM Institut Necker Enfants Malades - Centre de médecine moléculaire - UMR 8253 201420755D

Résumé du projet scientifique

Understanding life's mechanisms and dysfunctions requires an integrated approach combining genomics, transcriptomics, proteomics and metabolomics. Analyzing and integrating this heterogeneous, multi-scale data to elucidate systemic mechanisms require advances in computer science and mathematics. Through computational approaches and the development of algorithms for multi-scale analysis and machine learning, this interdisciplinary project aims to deepen our understanding of human physiology and design innovative diagnostic and therapeutic solutions.
The candidate will be expected to establish collaborations with INEM research teams in order to stimulate and structure this interdisciplinary work.

Résumé du projet d'enseignement

The project should be integrated within the Université de Paris Cité's Science, Technology and Health teaching teams.

Environnement Financier

• Total financé (dont package ANR) : 200 k€
• Total du projet : k€

Diffusion scientifique

The dissemination of the results will be done through world-class scientific productions: publications, patents, software... In addition, the results will be communicated to various targets such as scientific communities, media, decision makers, general public, schools, etc., with an adapted calendar. Specific tools may be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.

Science ouverte

The CNRS is developing a strong policy in favor of open science. Open science consists of making research results "as accessible as possible and closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its laboratories accessible , in particular through deposit in HAL. The data produced must also be made available and reusable, except for specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, to be more qualitative and to take into account all facets of the researcher's profession.

Science et société

The relationship between science and society is now recognized as a full dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will contribute to informing public decision-making. Participatory science initiatives may be initiated with actors from the project’s socio-economic and cultural eco-system.

Indicateurs

The activity will be evaluated in particular on the basis of scientific production (publications, software, patents, etc.), on institutional and private partnerships formalized by contracts, on international presence, on the promotion of work to multidisciplinary scientific communities, on innovation and its transfer to society and on scientific dissemination to non-specialist audiences.

Modalités d'organisation des auditions

Seul(e)s seront convoqué(e)s aux auditions les candidat(e)s sélectionné(e)s sur dossier par la commission de sélection