Profil Recherché

Titulaire d’un doctorat ou diplôme équivalent ou justifiant de titres et travaux scientifiques jugés équivalents par l’instance compétente de l’établissement. Il n’y a aucune condition d’âge ou de nationalité pour candidater. Tous les emplois CNRS sont accessibles aux personnes en situation de handicap en bénéficiant d’aménagement d’épreuves rendus nécessaires par la nature du handicap

Stratégie d'établissement

The proposed theme is in line with the “Life Sciences” thematic priority and the “Health and Environment” societal challenge of the CNRS Contract of Objectives and Performance (COP 2019-2021 and COMP in preparation). Longer life expectancy, for example, means an increase in neurodegenerative diseases, with severe consequences for patient care. In addition to the CNRS priority of deciphering the brain's role in cognitive functions (PEPR PROPSY), and to the promotion of mental health as “ Great National Cause 2025 ”, it is now essential to understand the underlying mechanisms of brain diseases to correct them.
In addition to characterizing the molecular mechanisms at involved in these pathologies, the discovery of relevant, actionable therapeutic targets is in rapid expansion. The characterization of innovative pharmacologically active molecules that are able to interfere with deleterious cerebral processes must be promoted to envisage their use in human clinics in the mid-term. The key challenge currently is to get these molecules/medicines to their site of action in the brain. An efficient delivery system (theranostic platform) enabling them to cross the blood-brain barrier (based on fundamental knowledge of its alterations in pathological conditions) while minimizing side effects needs to be proposed and validated. The recruitment of a young scientist in the field of research into therapeutic targets for CNS diseases and molecule delivery to the brain will enable us to make major advances in the definition of innovative therapeutic molecules and support the emergence of high-potential players for effective public/industrial research collaboration.

Stratégie du laboratoire d'accueil

INP's objectives are to study the interactions between neuronal, glial, endothelial and immune cells at a fundamental level, at different levels of integration (molecular models/animal models), and in various pathologies (neurodegenerative diseases, neurooncology and alterations of the blood-brain barrier (BBB)). The INP laboratory is a partner of Vect-Horus (a spin-off from the laboratory) within a Joint Research Laboratory. The partners have developed delivery strategies enabling therapeutic/diagnostic agents to cross the BBB. Several vectors have been jointly patented by Vect-Horus, CNRS and AMU. Licenses have been granted to international partners (RadioMedix, Ionis, Novo Nordisk). The INP laboratory aims to perpetuate and strengthen projects for the brain vectorization of innovative molecules, developed in-house or by public/private partners.

Stratégie Internationale

Recruitment is in line with the establishment's international strategy (CNRS/AMU). It will enable us to pursue and develop partnerships with academic groups (e.g., within the CIVIS Alliance) or international biotech or pharmaceutical companies, as INP and Vect-Horus have already demonstrated (see ongoing private partnerships above). The recruitment will enable INP to pursue its involvement in the construction of the European Research Area by coordinating HE projects (e.g. IMI project, MSCA DN, COST Action, CoEN, ERC...). It will also enable joint degrees to be obtained. All these actions are designed to continue attracting foreign students and post-docs on a long-term basis (more than 15 nationalities currently work at the INP).

Répertoire national des structures de recherche (RNSR) du laboratoire d'accueil

INP Institut Neurophysiopathologie (UMR7051)201220266F

Résumé du projet scientifique

The project is in line with one of INP's priorities, namely the development of strategies for delivering molecules of interest (therapy/imaging) to the brain. The development of innovative therapeutic/diagnostic agents is limited by the obstacle of crossing the blood-brain barrier (BBB). INP and Vect-Horus have already jointly developed and patented vectors for transporting these agents across the BBB. The project will focus on the development of new delivery strategies for CNS diseases. The choice of therapeutic targets will be made in conjunction with INP teams. The aim will be to facilitate the delivery of therapeutic agents to the brain to increase their efficacy. The candidate will interact with INP teams in a multidisciplinary context. He/she will be involved in interactions with industrial partners to reinforce the laboratory's value-added aspects.

Résumé du projet d'enseignement

The successful candidate will be involved in teaching activities at the University of Aix-Marseille in the field of biotechnologies and targeted therapy in brain pathologies.

Environnement Financier

• Total financé (dont package ANR) : 200 k€
• Total du projet : k€

Diffusion scientifique

The dissemination of the results will be done through world-class scientific productions: publications, patents, software... In addition, the results will be communicated to various targets such as scientific communities, media, decision makers, general public, schools, etc., with an adapted calendar. Specific tools may be developed such as websites, newsletters, meetings, international symposia, summer schools and conferences.

Science ouverte

The CNRS is developing a strong policy in favor of open science. Open science consists of making research results "as accessible as possible and closed as necessary". As such, the CNRS aims to make 100% of the texts of publications resulting from the work of its laboratories accessible , in particular through deposit in HAL. The data produced must also be made available and reusable, except for specific restrictions. In addition, the guiding principles of individual evaluation have been revised in accordance with the DORA declaration, to be more qualitative and to take into account all facets of the researcher's profession.

Science et société

The relationship between science and society is now recognized as a full dimension of scientific activity. The project will develop this dimension in synergy with all the partners. The resulting research work will contribute to informing public decision-making. Participatory science initiatives may be initiated with actors from the project’s socio-economic and cultural eco-system.

Indicateurs

The activity will be evaluated in particular on the basis of scientific production (publications, software, patents, etc.), on institutional and private partnerships formalized by contracts, on international presence, on the promotion of work to multidisciplinary scientific communities, on innovation and its transfer to society and on scientific dissemination to non-specialist audiences.

Modalités d'organisation des auditions

Seul(e)s seront convoqué(e)s aux auditions les candidat(e)s sélectionné(e)s sur dossier par la commission de sélection