Engineer (M/F) – Microphysiological Systems – PEPR MED-OOC

Job Description

Missions

The engineer will contribute to the development of an innovative microphysiological system aimed at modeling living tissues—particularly colonic tissue—in a relevant pathophysiological context. They will be responsible for designing advanced 3D structuring methods for hydrogel-based biomaterials, and integrating them into a microfluidic chip specifically designed to be compatible with confocal and light-sheet imaging techniques. Particular attention will be given to the analysis of tissue remodeling and the dynamic characterization of the mechanical properties of the materials during tissue formation and maturation.
This work is part of the ENVie demonstrator within the PEPR MED-OOC program, in which LAAS-CNRS is in charge of developing biomimetic extracellular matrices and integrated microfluidic devices, suitable for real-time observation and the integration of patient-derived tissues.

Activity

As part of the ENVie project, the engineer researcher will be responsible for finalizing the integration of a microfluidic device designed for the culture of colonic organoids, and for investigating the impact of the physico-chemical properties and 3D structuring of biomaterials on tissue development and remodeling dynamics.

Key activities will include:
The development of three-dimensional structuring methods for hydrogel-based materials (collagen, gelatin, hyaluronic acid), using photopolymerization or molding techniques;
The design and validation of coupled characterization protocols, combining mechanical measurements (elasticity, viscosity) with real-time microscopy techniques to monitor deformations and architectural changes in the materials during culture;
The integration of these structured matrices into microfluidic devices of the microphysiological systems type, with the goal of creating a functional colon-on-chip model.

Your Profil

Skills

Solid experience in microphysiological systems and/or tissue engineering
Proficiency in micro- and nanotechnologies, and/or 3D structuring techniques (3D printing, photopolymerization, laser ablation, molding)
Knowledge of advanced imaging techniques (confocal, fluorescence, electron microscopy, OCT, Brillouin...) will be highly valued.

Your Work Environment

This position is part of the ENVie demonstrator within the PEPR MED-OOC program, led by INSERM and LAAS-CNRS. The project aims to develop innovative tissue culture technologies that integrate 3D microenvironments, microfluidics, and high-resolution imaging to model digestive diseases (notably IBD and PDAC) on a chip.

The engineer will join the ELiA team at LAAS-CNRS, working in close collaboration with the MILE team, the I2C and TEAM technology services, and the laboratory's fabrication and imaging platforms (RENATECH, MultiFab, TRI-Genotoul). The project is embedded in a dynamic regional and national collaborative ecosystem focused on organ-on-chip technologies and personalized medicine.

Compensation and benefits

Compensation

Between 2496€ and 2662€ gross per month, depending on experience.

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions