Informations générales
Intitulé de l'offre : Postdoctoral fellow in protein biochemistry and structural biology (M/F) (H/F)
Référence : UPR4301-LAELEG-055
Nombre de Postes : 1
Lieu de travail : ORLEANS
Date de publication : mercredi 5 novembre 2025
Type de contrat : Chercheur en contrat CDD
Durée du contrat : 16 mois
Date d'embauche prévue : 1 janvier 2026
Quotité de travail : Complet
Rémunération : from 3041,58 € gross monthly depending on experience
Niveau d'études souhaité : Doctorat
Expérience souhaitée : 1 à 4 années
Section(s) CN : 20 - Biologie moléculaire et structurale, biochimie
Missions
SUMOylation is a protein post-translational modification (PTM) that controls virtually all physiological and pathophysiological processes. In this project we will study - using in-vitro biochemical, biophysical, and structural biology approaches - the SUMOylation of a key human DNA-repair protein. The project will involve protein expression and purification, interaction assays, structural modelling, and protein crystallography.
Activités
- Biochemistry and molecular biology techniques,
- Protein purification,
- Analysis of DNA-protein complexes
- Interpretation of results and writing of articles
- Presentation of results at conferences and scientific events
Compétences
We are looking for a motivated, dynamic, and independent junior postdoctoral researcher. The successful candidate will ideally have solid experience in protein biochemistry and be familiar with both protein PTMs and the DNA repair pathways. S/he should be able to carry out his/her research project independently and work closely with other team members. S/he should also be able to collaborate with external laboratories
Contexte de travail
The CBM (UPR4301-CNRS) is located on the CNRS campus in Orléans, which has 6,300 m2 of modern office and lab space. It is home to biologists, physicists and chemists who work in close collaboration to understand the molecular mechanisms that lead to the development of certain diseases such as cancer. The research centre provides an interactive and international working environment, with a wide range of instruments suitable for multidisciplinary research, from cellular and preclinical imaging to crystallography.
This project will be carried out under the scientific guidance of Dr Marcin SUSKIEWICZ within the "Protein post-translational modifications and DNA repair: structure, function, and dynamics" group, co-led by Dr Bertrand CASTAING and Dr Marcin SUSKIEWICZ, at the Centre de Biophysique Moleculaire in Orleans
The project is part of a larger project funded by Institut National du Cancer (INCa), program PLBio. The postdoc will be part of a dynamic interdisciplinary team and will be in contact with a network of collaborators.
Contraintes et risques
Standard risks associated with biochemical work.