Missions

The complex interaction between plants and pathogens involves profound changes in the molecular and physiological states of both organisms. A growing body of research highlights the crucial role of epigenetic regulation in orchestrating plant defense mechanisms. Our recent work has shown that bacterial virulence factors can induce extensive changes in DNA methylation, with similar modifications observed in the plant methylome during infection. However, the functional significance and precise timing of these chromatin alterations remain poorly understood. Furthermore, the effects of bacterial infection on small RNA movement and the methylation patterns of the next generation warrant further investigation.
As part of the EPIPAT ERC-funded research project, we are seeking a creative, meticulous, and inquisitive scientist to investigate the dynamics of the plant epigenome during bacterial infection by generating and analyzing cutting-edge functional genomics datasets.

Activités

The successful candidate will study the interactions between bacterial infections and reproductive processes in Arabidopsis thaliana. This research will involve performing high-throughput library preparations and conducting comprehensive data analyses to characterize the chromatin landscape and working on key molecular players involved in the plant's defense response and during reproduction. Further functional characterization will rely on a broad range of classical molecular and genetic techniques, including PCR, qPCR, genetic crosses, and detailed phenotypic analyses.
The candidate will be responsible for integrating multi-level datasets to develop a cohesive understanding of epigenomic regulation in plant immunity. They will be expected to critically interpret experimental results and communicate findings effectively through written reports, scientific publications, and oral presentations in English. The position may also include opportunities to participate in the training, mentorship, and supervision of students, as well as to collaborate closely with other members of the research team and external partners.

Compétences

We are looking for a highly motivated and curious individual with a strong collaborative spirit and a proven track record in functional genomics. The ideal candidate should hold a PhD, or have equivalent experience, in molecular biology, genetics, bioinformatics, or a related field, and possess extensive hands-on experience in generating high-throughput epigenomic and transcriptomic libraries. A solid background in the analysis of large-scale genomics datasets is essential. Proficiency in standard molecular biology techniques and experience with Arabidopsis growth and genetics are also required.
Expertise in multiplexed CRISPR approaches will be considered an asset. Previous experience in plant epigenetics, small RNAs, or plant reproduction is desirable but not mandatory. Outstanding communication and scientific writing skills in English are essential for this role.

Contexte de travail

The research will be carried out in a vibrant and collaborative scientific environment at the Institute of Plant Molecular Biology (IBMP) in Strasbourg, which provides access to state-of-the-art facilities for imaging, genomics, and plant molecular biology. This position, funded by an ERC grant, offers a unique opportunity to address fundamental questions at the intersection of epigenetics, sexual reproduction and plant–pathogen interactions.
The successful candidate will join the Epigenetic Regulation and Sexual Reproduction in Plants team (www.jullienlab.com), an international and supportive group committed to scientific excellence and the professional development of its members. The position includes personalized mentoring, opportunities to acquire new technical and analytical skills, and support for expanding the candidate's scientific network and publication record.

Contraintes et risques

The position may involve travel for scientific conferences or collaborative research. Standard laboratory risks are present, including the handling of chemical products and biological agents, work in controlled thermal environments, and extended periods of computer use.