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Reference : UMR8576-MARRAT-014
Workplace : VILLENEUVE D ASCQ
Date of publication : Friday, November 20, 2020
Type of Contract : FTC Scientist
Contract Period : 12 months
Expected date of employment : 1 January 2021
Proportion of work : Full time
Remuneration : gross monthly salary € 2,675.27 < 2 years of experience
Desired level of education : 5-year university degree
Experience required : Indifferent
The UGSF, Unit of Structural and Functional Glycobiology (UMR / CNRS 8576), offers a one year position on a project entitled "Development of a method for the determination of the O-acetylated form of GD2 in tumor samples" .
The candidate will be required to work on the implementation of tools allowing the quantitative analysis of ganglioside O-acetyl-GD2 (OAcGD2) in different biological samples. The OAcGD2 antigen is expressed in cancerous tissue of neuroectodermal origin.
The method of identification and relative quantification of this antigen by mass spectrometry, published by Cavdarli et al. (2020), will be used and adapted to allow the determination of the antigen in cancer cells, then in tumor samples. This work will mainly be carried out by the use of mass spectrometry devices from the Pagès platform (UMS 2014). The objective of this program is the validation of the assay method in tumor samples in order to allow future clinical use.
Desired experience: 1 to 2 years in the same type of position
Management skills: Management and coordination of collaborative research projects, organization, writing (presentation of results, study reports)
Technical skills: Molecular and cellular biology techniques, good knowledge of Mass Spectrometry, good knowledge of glycolipids
Language skills: English essential, French
Computer skills: MS Office and MS Excel required + Experience in statistical and scientific graphing software desirable
Human skills: Dynamism, rigor, good communication, team / network work, sense of analysis and synthesis, sense of quality
The candidate will work in building C9, Unit of Structural and Functional Glycobiology (UMR / CNRS 8576), University of Lille, Villeneuve d'Ascq (59655), in the team of Dr Anne Harduin-Lepers (regulation of terminal glycosylation) in collaboration with Dr Sophie Groux-Degroote.
She will have to travel to OGD2 Pharma, collaborator of the project, and will work jointly on certain aspects of the project with a CIFRE doctoral student.
Constraints and risks
Regular trips to be planned in France at a rate of 2-3 days per month
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