Informations générales
Intitulé de l'offre : Post doctoral researcher in bioproduction (M/F) (H/F)
Référence : UMR8175-FLOGAZ0-006
Nombre de Postes : 1
Lieu de travail : PARIS 06
Date de publication : lundi 8 septembre 2025
Type de contrat : Chercheur en contrat CDD
Durée du contrat : 10 mois
Date d'embauche prévue : 1 novembre 2025
Quotité de travail : Complet
Rémunération : Between 2 991,58 € and 4 756,76 € gross monthly depending of experience
Niveau d'études souhaité : Doctorat
Expérience souhaitée : Indifférent
Section(s) CN : 28 - Pharmacologie, bio-ingénierie, imagerie, biotechnologie
Missions
The agent will be responsible for conducting experiments and simulations of extracellular vesicle bioproduction in automated bioreactors. They will model hydrodynamic conditions and characterize production under mechanical stress (turbulence-based process). They will also develop a digital twin model of the bioproduction conditions.
Activités
Numerical simulation
Bioproduction in bioreactors
Extracellular vesicle purification
Multimodal characterization of extracellular vesicles
AI-driven digital twin modeling
Compétences
Modelisation - AI- Molecular and cellular biology - Hydrodynamic - Bioengineering
Contexte de travail
The new multidisciplinary unit NABI (Nanomedicine, Extracellular Biology, Integratome and Health Innovations), located on the Saint Germain Campus of Université Paris Cité (45 rue des Saints Pères, 75006 Paris), was established on January 1, 2025. It brings together around 70 collaborators—including physicists, biologists, pharmacists, engineers, and physicians—of which about thirty are permanent staff, under the joint supervision of CNRS, INSERM, and Université Paris Cité.
NABI's scientific objectives are to develop new therapies based on biological nano-objects (extracellular vesicles) or synthetic nano-objects (activatable metallic nanoparticles) for the delivery of personalized treatments for hard-to-treat diseases.
Studying nano-objects in biological fluids requires transdisciplinary approaches (physics, engineering, cell and molecular biology, immunology, etc.) extending all the way to clinical practice, as well as dedicated technical and analytical resources (super-resolution microscopy, nanosensors, microfluidics, etc.), combined with systematic multimodal and multiscale exploration supported by AI-driven analysis.
These innovative methodologies are developed within NABI and in partnership with the industrial integrator IVETh, a technology hub dedicated to the characterization, bioproduction, and engineering of extracellular vesicles and nanovectors for diagnostics and personalized therapies. The agent will join the multidisciplinary “Nanobiotherapies” team as part of the ERC-funded Exocyther project.