Post-doctoral position M/F - Binding of Leaderless mRNA on archaeal ribosome
New
- Researcher in FTC
- 9 month
- Doctorate
This offer is available in English version
This offer is open to people with a document recognizing their status as a disabled worker.
Offer at a glance
The Unit
Laboratoire de Biologie Structurale de la Cellule
Contract Type
Researcher in FTC
Working hHours
Full Time
Workplace
91128 PALAISEAU
Contract Duration
9 month
Date of Hire
10/09/2026
Remuneration
3131,32 € à 4341,70 €
Apply Application Deadline : 16 July 2026 23:59
Job Description
Missions
Understanding the molecular mechanisms of translation of leaderless messenger RNAs in the archaeon Saccharolobus solfataricus.
The successful candidate will primarily use molecular biology and biochemistry—including structural biology, particularly cryo-EM—to characterize translation initiation complexes assembled on leaderless messenger RNAs.
Activity
Use of in vitro translation assays to characterize the influence of the 5'UTR region and the aS26 protein on translation efficiency in the context of a messenger RNA with a (potentially modified) 5' untranslated region (5'UTR) and a leaderless sequence.
Initiation complexes formed on leaderless messenger RNAs will be isolated from cell extracts and then characterized by cryo-electron microscopy to determine the three-dimensional structures of these complexes at high resolution.
Your Profil
Skills
The candidate (M/F) must hold a Ph.D. in biology, chemistry, or biophysics, have a strong background in cryo-EM and the purification of macromolecular complexes, and have at least one year of experience following completion of their dissertation.
Your Work Environment
École Polytechnique offers a unique interdisciplinary environment, including laboratories dedicated to molecular and cellular biology, chemistry, biomechanical engineering, biophysics, optics, computer science, and applied mathematics. École Polytechnique is a member of the Institut Polytechnique de Paris. It is also part of the dynamic Saclay science cluster, south of Paris. These organizations combine their strengths to foster excellence in research.
The project will be conducted within the “Translation Mechanisms” team led by Emmanuelle Schmitt and Yves Mechulam at the “Structural Cell Biology” (BIOC) laboratory at École Polytechnique, https://portail.polytechnique.edu/bioc/en/recherche/translation-mechanisms. The BIOC laboratory is a joint research unit of the CNRS and École Polytechnique, located on the Palaiseau campus and fully equipped to carry out the project. In addition, the laboratory has privileged access to CIMEX (Interdisciplinary Center for Electron Microscopy at the École Polytechnique), which is equipped with a 300 kV Titan Themis electron microscope fitted with a Falcon 3 direct electron detector.
Constraints and risks
No specific risks have been identified.
Compensation and benefits
Compensation
3131,32 € à 4341,70 €
Annual leave and RTT
44 jours
Remote Working practice and compensation
Pratique et indemnisation du TT
Transport
Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€
About the offer
| Offer reference | UMR7654-EMMSCH-006 |
|---|---|
| CN Section(s) / Research Area | Molecular and structural biology, biochemistry |
| Relevant experience | 1 to 4 years |
About the CNRS
The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.
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