Postdoctoral Researcher in Neurodevelopment, Organoids & Genomics (M/F)

Job Description

Missions

The project aims to investigate lineage progression and the mechanisms that drive neuronal diversification during human nervous system development. It will rely on organoid models developed in our laboratory, as well as human embryonic tissues, combined with global omics approaches, particularly at the single-cell level. The objective is to understand how signaling pathways regulate the genetic networks underlying cell-fate decisions and the emergence of neuronal diversity in the human hindbrain and spinal cord.
The recruited candidate will be responsible for conducting experiments using various organoid models and human tissues including single cell-rna seq expriments and performing subsequent bioinformatic analyses. The candidate will also be expected to present their work at seminars and conferences, contribute to grant applications, and participate in the writing of scientific publications.

Activity

- Perform genomics experiments (RNA-seq, ChIP-seq and ATAC-seq), with particular emphasis on single-cell RNA-seq and likely spatial transcriptomic. The project will require testing and implementing new single-cell RNA-seq and spatial transcriptomic methods, especially on fixed tissues.
- Culture human pluripotent stem cells and differentiate them into organoids; analyze differentiation using omics approaches, PCR, and histological methods.
- Analyze post-mortem embryonic tissues using omics techniques, PCR, and histology.
- Perform confocal imaging and subsequent image analysis, including quantitative data analysis.
- Programming/coding for data assembly and analysis, including statistical analyses, of both newly generated datasets and existing datasets using bioinformatics tools.
- Integrate computational and experimental results.
- Interpret experimental and computational findings.
- Maintain awareness of relevant scientific literature in the field.
- Prepare scientific reports and publications, including figure preparation and manuscript writing.
- Present research findings within the team and at scientific meetings.
- Contribute to the preparation of grant applications.

Your Profil

Skills

- Strong interest in developmental biology.
- Prior expertise in genomics and subsequent bioinformatics analysis is a necessity.
- Demonstrated experience in single-cell RNA-seq and associated bioinformatic analyses.
- Experience with epigenomic and/or transcriptomic approaches (particularly ChIP-seq and ATAC-seq), including downstream bioinformatic analysis, will be considered a major asset.
- Experience in iPSC culture and differentiation is appreciated but not mandatory. Direct technical support for cell culture, including organoid differentiation, will be available.
- Excellent academic track record, with at least one first-author publication accepted or, for candidates still completing or having just completed their PhD, at minimum submitted.
- Ability to work both independently and collaboratively, with strong team spirit.
- Good communication skills and strong proficiency in spoken and written English.

Your Work Environment

The Jacques Monod Institute, located in the heart of Paris, is a leading international research center with a strong collaborative culture, offering a highly interactive scientific environment and access to state-of-the-art technological platforms. The Ribes/Nedelec team provides a stimulating research setting at the interface of neurodevelopment, cell biology, and genomics. We employ a wide range of techniques — including organoids, embryonic tissues, omics approaches, and live imaging — to investigate the principles of cell-fate specification and tissue morphogenesis. We have recently moved into newly renovated facilities featuring dedicated culture rooms for human organoid research. English is the working language for laboratory meetings, seminars, and daily communication.

Compensation and benefits

Compensation

From 3131€ grossly per month

Annual leave and RTT

44 jours

Remote Working practice and compensation

Pratique et indemnisation du TT

Transport

Prise en charge à 75% du coût et forfait mobilité durable jusqu’à 300€

About the offer

About the CNRS

The CNRS is a major player in fundamental research on a global scale. The CNRS is the only French organization active in all scientific fields. Its unique position as a multi-specialist allows it to bring together different disciplines to address the most important challenges of the contemporary world, in connection with the actors of change.

CNRS

The research professions