Missions

Study scientific needs and propose techniques and methods for manufacturing and mechanically and biologically characterizing microfluidic biochips for cell culture as part of the APOLLO project.

Activities

• Negotiate with the project's industrial partners the functional specifications and draw up the technical specifications for the manufacture of microfluidic chips for liver cell culture, based on non-adsorbent polymers with or without oxygen permeability.
• Organize production follow-up : manufacture, validate and qualify microfluidic devices in terms of mechanical (modulus of elasticity, etc.), surface and biological properties (absence of cytotoxicity, maintenance of cell functions).
• Perform or supervise the performance of physical and biological measurements related to the project, interpret and validate them.
• Train and inform newcomers to the project on the principles and implementation of experimental microfabrication devices, and ensure the safe operation of manufacturing and cell culture processes.
• Train and assist project participants in the principles and implementation of one or more materials characterization techniques.
• Plan the use of equipment, forecast and manage an operating budget for the project
• Collaborate for expert purposes with other laboratories or companies
• Structure a technology watch
• Present, disseminate and promote achievements

Skills

-Biomaterials: shaping and properties (in-depth knowledge)
- Biocompatibility (in-depth knowledge)
- Microfabrication and microfluidics (general knowledge)
- Cell biology and analytical techniques (general knowledge)
- Health and safety regulations
- Environment and professional networks (general knowledge)
- Written and oral presentation techniques
- English language: B2

Work Context

The person recruited will work in the BMBI laboratory (UMR CNRS 7338). Work will be carried out on the microfluidic/cellular microsystems platform and in the cell culture laboratory (L2).
The person recruited will be required to work in collaboration with researchers, PhD students and trainees from the CBB team, involved in the BPI-funded APOLLO project. The overall aim of this project is to propose a device for assessing the bioavailability and non-toxicity of biomedicines (notably antibodies, nanobodies, etc.), using perfused and parallelized biochips. The project is led by Fluigent, in collaboration with Demgy.

Constraints and risks

Compliance with Health and Safety rules in force on the laboratory's various platforms.
Travel to partner sites