Missions

The postdoctoral researcher will work on a translational project funded by the ANR 2024, aiming to better understand chronic respiratory diseases through cutting-edge genomic and cell biology approaches. The researcher will contribute to uncovering a novel regulatory pathway involved in maintaining cellular balance within the respiratory tract, in the context of chronic respiratory conditions such as Chronic Obstructive Pulmonary Disease (COPD) and ciliary dyskinesias.

Activités

The approaches used by the laboratory include primary human bronchial epithelial cell cultures differentiated at the air-liquid interface, targeted gene inactivation using CRISPR-Cas9, imaging, single-cell and spatial transcriptomic analyses, as well as chromatin studies. The project also involves a bioinformatics component, to which the postdoctoral researcher will contribute in collaboration with the team's bioinformaticians.
The project is carried out in close collaboration with clinical teams from three university hospitals (CHUs), as well as the laboratory's genomics and bioinformatics platforms.

Compétences

The candidate must demonstrate proven expertise in several of the following areas: cell and molecular biology, developmental biology, genomics, and respiratory physiology.
A background in lung biology or pulmonary disease research is desirable.
While bioinformatics skills are not required to apply, training and experience in bioinformatics will be highly valued.
Ideally, the candidate should already have postdoctoral experience and be motivated to apply for competitive research scientist positions.

Contexte de travail

The position is based at the Institute of Molecular and Cellular Pharmacology (IPMC) in Valbonne – Sophia Antipolis (Alpes-Maritimes, France). The IPMC hosts 22 research teams and shared core facilities, with a total staff of over 250 people.
The successful candidate will join the “Physiological Genomics of Eukaryotes” research team, led by Dr. Pascal Barbry, and will work on projects conducted by Dr. Laure-Emmanuelle Zaragosi. The team follows a quantitative biology approach and brings together experimental scientists and bioinformaticians. It was the first French team to take part in the international Human Cell Atlas consortium.
The project is carried out in close collaboration with a team from the University of Reims Champagne-Ardenne and a team from the Trousseau University Hospital in Paris.

Le poste se situe dans un secteur relevant de la protection du potentiel scientifique et technique (PPST), et nécessite donc, conformément à la réglementation, que votre arrivée soit autorisée par l'autorité compétente du MESR.