Missions

The selected candidate will be integrated in the team who studies the signaling pathways responsible for the assembly of the nuclear pore complexes during cell cycle progression in healthy and diseased cells, in the Department of Functional Genomics and Cancer at the IGBMC. He/she will work under direct supervision of the team leader Izabela Sumara in collaboration with other members of the INCa program (PLBIO22-086).

Activités

- The selected candidate will study the mechanisms of the assembly of nuclear pores in healthy and cancerous cells.
The scientific program and tasks: Asymmetric di-methylation (ADMA) of arginine residues is a key post-translational modification involved in regulating chromatin structure, RNA processing, and gene expression. Nuclear pore complexes (NPCs) are large protein assemblies embedded in the nuclear envelope (NE) that mediate bidirectional transport between the nucleus and cytoplasm. Additionally, NPCs establish direct contacts with chromatin and contribute to gene regulation. Despite their nuclear localization and function, it remains unclear whether ADMA directly or indirectly influences NPC assembly. Our preliminary results demonstrate a crucial role for ADMA in the proper localization of nucleoporins (Nups), the building blocks of NPCs, and in correct NPC assembly at the NE in human cells.

- He/She will study the exact molecular mechanisms of how ADMA regulates NPC assembly in healthy and cancer cells using a combination of cell biology, high-end microscopy and biochemical approaches.

- He/she will actively participate in the communication of his/her results in the laboratory and at the institute.

-He/She will supervise the work of master students.

Compétences

- The selected candidate must hold a PhD in Biology and have experience in the field of molecular and cellular biology, cell culture and microscopy
- Scientific knowledge, scientifc rigor, excellent organizaiton skills and proficiency in English (C1 level).
- Dynamic and respectful personality, teamwork and strong motivation

Contexte de travail

The CNRS (National Center for Scientific Research), certified HR Excellence in Research, is one of the world's leading multidisciplinary public research organizations. The IGBMC (Institute of Genetics and Molecular and Cellular Biology), one of Europe's leading biomedical research centers, is a joint research unit associated with the CNRS, INSERM, and the University of Strasbourg.
The successful candidate will work at the IGBMC and benefit from an exceptional international scientific environment. The IGBMC has around 40 teams divided into four scientific departments and state-of-the-art technological platforms on site.
The direct scientific collaborator on the INCa-funded project is Dr. Dominique Weil (IBPS, Paris). In addition, the team's nuclear pore research project involves numerous national and international collaborators, including Bruno P. Klaholz, Ali Hamiche, Christelle Golzio, Lionel Pintard, Guillaume Chevreux, and Yannick Schwab.

The selected candidate will have access to the CROUS restaurant.
The site is accessible by tram (line A, Campus Illkirch station) from Strasbourg train station or by car (parking available). Public transportation costs are partially covered.

Contraintes et risques

No on-call duty, no requirement for shift or weekend work, and no work involving mice or other animals. Occasional travel to international scientific conferences and meetings related to the project topic is expected.